Biochemical Basis of Inflammatory Response in Nursing: Implications for Patient Care and Treatment | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 13, December 2024, Page 1373-1386 PDF (704.1 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/ejchem.2024.336228.10798 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Seham Abdu Hussain Althurwi1; Fahdah Fahad Alanazi2; Mona Ahmed Kariri2; Bdoor Hassan Alenzie3; Abdullah Duwayhim Abdullh4; Bairum Ibrahim Khairi5; Fatimah Saeed Al Shahrany6; Lulua Mohammed Alateiwi7; Khulud Shaya Salem Alqahtani8; Jawaher Mnwer Alrashedi9; Salma Ali Hassan Magbol5; Wafa Saad Alharthi9; Montaha Ali Shatti Alshammari9; Ayat Ibrahim Zaidan5; Nuha Falah Alharbi7 | ||||
| 1Alaidabi General Hospital, Ministry of Health, Saudi Arabia | ||||
| 2First Health Cluster, Ministry of Health, Saudi Arabia | ||||
| 3The first health cluster in Riyadh, Primary Health Care Center in Saudi District, Al Kharj, Ministry of Health, Saudi Arabia | ||||
| 4Riyadh First Health Cluster, Ministry of Health, Saudi Arabia | ||||
| 5Jazan Health Cluster, Ministry of Health, Saudi Arabia | ||||
| 6Third health cluster, Ministry of Health, Saudi Arabia | ||||
| 7Aljazeerah PHC-Riyadh 2nd cluster, Ministry of Health, Saudi Arabia | ||||
| 8Ministry of Health branch in Riyadh, Ministry of Health, Saudi Arabia | ||||
| 9Ministry of Health branch in Riyadh, Saudi Arabia | ||||
| Abstract | ||||
| Background: Inflammation is a fundamental immune response that defends the body against injury and infection. However, chronic inflammation is linked to various pathological conditions, including autoimmune disorders and cardiovascular diseases. The biochemical mechanisms underpinning inflammation involve multiple signaling pathways and mediators, each contributing to the body’s immune and healing processes. Nursing professionals are integral to managing inflammatory disorders, bridging biochemical knowledge with clinical care to enhance patient outcomes. Aim: This article aims to analyze the biochemical basis of inflammation, emphasizing the role of nursing in managing inflammatory responses through an understanding of cellular signaling and mediators. The goal is to provide insight into how nursing practices can mitigate inflammation’s adverse effects and promote effective patient care. Methods: A review of current literature was conducted, focusing on the biochemical pathways involved in inflammation and the role of nursing in inflammatory disorder management. The study covers three principal signaling pathways: the NFκB pathway, Mitogen-Activated Protein Kinase (MAPK) pathway, and Janus Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway, along with other key inflammatory mediators, including the kinin system, free radicals, histamine, and cell adhesion molecules. Results: The study finds that the NFκB, MAPK, and JAK-STAT pathways play a crucial role in regulating inflammatory responses. Inflammatory mediators like histamine and free radicals contribute to the progression of inflammation, and their dysregulation can exacerbate chronic inflammatory conditions. Nurses’ understanding of these pathways enables early intervention, improved patient monitoring, and effective symptom management, which are essential for reducing inflammation and preventing complications. Conclusion: An in-depth knowledge of the biochemical aspects of inflammation allows nursing professionals to better assess and manage inflammatory disorders, aligning therapeutic interventions with the underlying molecular processes. By incorporating biochemical insights into patient care, nurses can optimize treatment outcomes and contribute to the holistic management of inflammation-related disorders. Further training in biochemical mechanisms is recommended to strengthen nursing practices and patient care standards. | ||||
| Keywords | ||||
| Inflammation; NFκB pathway and MAPK pathway; JAK-STAT pathway; Patient care; Biochemical mechanism | ||||
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