Intranasal dexmedetomidine versus intranasal ketamine as a pre-anesthetic medication in pediatrics | ||||
| Ain-Shams Journal of Anesthesiology | ||||
| Volume 16, Issue 1, 2024 PDF (339.72 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asja.2024.290531.1110 | ||||
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| Authors | ||||
Safaa Ishak Ghaly  1; Doaa Ahmed Diaa El-din2; Dalia Mohammed3; Douaa Galal Mohammad Ibrahim4
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| 1Ain Shams University | ||||
| 2Ain Shams University,Faculty of Medicine,Anesthesia | ||||
| 3Ain Shams University,faculty of medicine | ||||
| 4Ain Shams University,Faculty of Medicine | ||||
| Abstract | ||||
| Background: Management of pre-operative anxiety is important in pediatric anesthesia. Ketamine and dexmedetomidine have been used as pre-anesthetic medications to alleviate stress . Objectives: This prospective randomized trial compared intranasal dexmedetomidine versus intranasal ketamine as a premedication in pediatric surgery. Patients and methods: Ninety children aged 1-8 years of either sex, scheduled for minor elective surgeries were randomly divided into 2 groups , 45 each. Thirty minutes before induction, group D received intranasal Dexmedetomidine (1 mcg/kg), while group K received intranasal Ketamine (2 mg/kg). Patients were compared for sedation score ,parent separation score , hemodynamics and possible side effects. Results: Sedation score was significantly lower in group D at 10, 20 and 30 minutes after drug administration. Parent separation score was in favor of group D at 10 and 20 minutes of drug administration and was comparable between both drugs at 30 minutes. Children in group D achieved satisfactory sedation of 91.1% and significant decrease in heart rate and blood pressure 30 minutes after drug administration and during the intraoperative period, while no difference was observed at 10 and 20 minutes . No difference in oxygen saturation between the 2 groups was observed. Shivering was significantly higher in group K while postoperative nausea and vomiting showed no significant difference between both groups. Conclusion: Intranasal dexmedetomidine and intranasal ketamine can be used effectively and safely as pre-anesthetic medications in children as regards sedation level and parental separation, with superiority of dexmedetomidine in sedation scores ,heart rate and blood pressure response. | ||||
| Keywords | ||||
| intranasal; dexmedetomidine; ketamine; pre-anestheic; pediatrics | ||||
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