Adverse effects of chemotherapy and the interaction with anesthesia: a narrative review

DELGADO, MARINA AYRES; Holzmann Neto, Pual; Drumond, Andre Luis Vieira; de Souza, Geovana Torres; Mendonça, Andre dos Santos; Dall&quot;Aqua, Camila Gomes; Oliveira, Bruna Carvalho; Castello Branco, Bruno Vinícius; do Nascimento, David Ribeiro

doi:10.21608/asja.2024.275440.1076

	Adverse effects of chemotherapy and the interaction with anesthesia: a narrative review
Ain-Shams Journal of Anesthesiology
Volume 16, Issue 1, 2024 PDF (256.24 K)
Document Type: Review Articles
DOI: 10.21608/asja.2024.275440.1076
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Authors
MARINA AYRES DELGADO ¹; Pual Holzmann Neto ²; Andre Luis Vieira Drumond ³; Geovana Torres de Souza ²; Andre dos Santos Mendonça ⁴; Camila Gomes Dall"Aqua ²; Bruna Carvalho Oliveira ⁵; Bruno Vinícius Castello Branco ²; David Ribeiro do Nascimento ⁵
¹Av Caranda&amp;iacute; 353 1601
²Hospital das Clinicas UFMG/Ebserh
³Hospital das Clinica UFMG/Ebserh
⁴Hospital das Clinicas UFMG/Ebserh
⁵Hospital das Clínicas UFMG/Ebserh
Abstract
Introduction: Many cancer patients have their main tumors surgically removed with the goal of curing them, or as part of palliative care. When a patient receives general anesthesia, the side effects of the administered chemotherapy regimens must be considered, especially those that may have significant repercussions during anesthetic care. The aim of this study is to review the existing literature to identify adverse effects of chemotherapy and known interactions between chemotherapy and anesthetic drugs, analyze the mechanisms underlying these interactions, and discuss relevant clinical implications. Methods: This integrative review searched for articles using the search terms: chemotherapy, anesthetic drugs, interaction, adverse effects and drug combination. Discussion: Negative perioperative outcomes may be related to the chemotherapy. Regarding the type of oncological surgery, factors such as blood loss, hypothermia and extended operative time influence the increase in morbimortality. Many anesthetic drugs are related to immunomodulation and moreover interact with chemotherapy, which may get better or worse cancer patients. Conclusion: It is crucial for anesthetists to have a comprehensive understanding of the potential adverse effects of chemotherapy drugs and their interactions with anesthetics.
Keywords
chemotherapy; adverse drug event; anesthetics agents; antineoplastic drug; cancer treatment protocol


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