Mitigating Acute Kidney Injury: The Role of Naringenin in Rhabdomyolysis
Doghish, A., S. Elballal, M., A. Elrebehy, M., A. Ibrahim, R., A. Khater, H., H. Eldidamoney, F., H. Ali, M., T. Gabr, Y., S. Adel, A., G. Farouk, A., E. Georgy, M., S. Rezk, M., M. Shawky, Z., M. Abdelhady, R., H. Ashry, S., M. Abdelwahab, J. (2024). Mitigating Acute Kidney Injury: The Role of Naringenin in Rhabdomyolysis. EKB Journal Management System, (), 1-9. doi: 10.21608/ijhr.2024.332558.1033
Ahmed S. Doghish; Mohammed S. Elballal; Mahmoud A. Elrebehy; Randa A. Ibrahim; Hamsa A. Khater; Farah H. Eldidamoney; Menna H. Ali; Youmna T. Gabr; Aya S. Adel; Amira G. Farouk; Merna E. Georgy; Maqar S. Rezk; Zahra M. Shawky; Rokaya M. Abdelhady; Shimaa H. Ashry; Jihad M. Abdelwahab. "Mitigating Acute Kidney Injury: The Role of Naringenin in Rhabdomyolysis". EKB Journal Management System, , , 2024, 1-9. doi: 10.21608/ijhr.2024.332558.1033
Doghish, A., S. Elballal, M., A. Elrebehy, M., A. Ibrahim, R., A. Khater, H., H. Eldidamoney, F., H. Ali, M., T. Gabr, Y., S. Adel, A., G. Farouk, A., E. Georgy, M., S. Rezk, M., M. Shawky, Z., M. Abdelhady, R., H. Ashry, S., M. Abdelwahab, J. (2024). 'Mitigating Acute Kidney Injury: The Role of Naringenin in Rhabdomyolysis', EKB Journal Management System, (), pp. 1-9. doi: 10.21608/ijhr.2024.332558.1033
Doghish, A., S. Elballal, M., A. Elrebehy, M., A. Ibrahim, R., A. Khater, H., H. Eldidamoney, F., H. Ali, M., T. Gabr, Y., S. Adel, A., G. Farouk, A., E. Georgy, M., S. Rezk, M., M. Shawky, Z., M. Abdelhady, R., H. Ashry, S., M. Abdelwahab, J. Mitigating Acute Kidney Injury: The Role of Naringenin in Rhabdomyolysis. EKB Journal Management System, 2024; (): 1-9. doi: 10.21608/ijhr.2024.332558.1033

Mitigating Acute Kidney Injury: The Role of Naringenin in Rhabdomyolysis

International Journal for Holistic Research
Articles in Press, Accepted Manuscript, Available Online from 05 December 2024    PDF (2.76 M)
Document Type: Original Article
DOI: 10.21608/ijhr.2024.332558.1033
Authors
Ahmed S. Doghish* 1; Mohammed S. Elballal1; Mahmoud A. Elrebehy2; Randa A. Ibrahim1; Hamsa A. Khater3; Farah H. Eldidamoney3; Menna H. Ali3; Youmna T. Gabr3; Aya S. Adel3; Amira G. Farouk3; Merna E. Georgy3; Maqar S. Rezk3; Zahra M. Shawky3; Rokaya M. Abdelhady3; Shimaa H. Ashry3; Jihad M. Abdelwahab3
1Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt
2Department of Biochemistry, Faculty of Pharmacy, Galala University, New Galala City, 43713, Suez, Egypt
3Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt
Abstract
Rhabdomyolysis, which is defined as the breakdown of skeletal muscle, can lead to severe problems such as acute kidney injury (AKI), which represents a serious medical emergency. Naringenin is a bioflavonoid that may be found in citrus fruits. The purpose of this study is to evaluate the preventive benefits of naringenin against glycerol-induced AKI in ants. In this experiment, twenty-four male Wistar rats were randomly assigned to one of three groups: control, glycerol-treated, or naringenin-pretreated. Histopathological investigations and biochemical studies were carried out to evaluate the function of the kidneys and the extent of the damage to the tissues. According to the findings, naringenin was able to dramatically lower kidney damage markers such as renal somatic index, serum creatinine, and blood urea nitrogen levels when compared to the group that was given glycerol. A significant improvement in kidney architecture was observed in the rats who were treated with naringenin, as determined by histological examinations. These findings demonstrate that naringenin has a protective effect against AKI caused by rhabdomyolysis, possibly because of its antioxidant capabilities. This highlights the therapeutic potential of naringenin in the management of kidney-related problems.
Keywords
Acute Kidney Injury; Rhabdomyolysis; Naringenin; oxidative stress
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