Association Between DEPDC5 and PNPLA3 Variants and the Risk of Hepatocellular Carcinoma in HCV-Infected Patients in Egypt
Roshdy, O., El-Daly, M., Mohamed, M., Abdel-Hamid, M., Zanaty, M. (2024). Association Between DEPDC5 and PNPLA3 Variants and the Risk of Hepatocellular Carcinoma in HCV-Infected Patients in Egypt. EKB Journal Management System, 10(6), 65-77. doi: 10.21608/jbaar.2024.395621
Osama M. Roshdy; Mai M. El-Daly; Mohamed Gamal Mohamed; Mohamed Abdel-Hamid; Mohamed I. Zanaty. "Association Between DEPDC5 and PNPLA3 Variants and the Risk of Hepatocellular Carcinoma in HCV-Infected Patients in Egypt". EKB Journal Management System, 10, 6, 2024, 65-77. doi: 10.21608/jbaar.2024.395621
Roshdy, O., El-Daly, M., Mohamed, M., Abdel-Hamid, M., Zanaty, M. (2024). 'Association Between DEPDC5 and PNPLA3 Variants and the Risk of Hepatocellular Carcinoma in HCV-Infected Patients in Egypt', EKB Journal Management System, 10(6), pp. 65-77. doi: 10.21608/jbaar.2024.395621
Roshdy, O., El-Daly, M., Mohamed, M., Abdel-Hamid, M., Zanaty, M. Association Between DEPDC5 and PNPLA3 Variants and the Risk of Hepatocellular Carcinoma in HCV-Infected Patients in Egypt. EKB Journal Management System, 2024; 10(6): 65-77. doi: 10.21608/jbaar.2024.395621

Association Between DEPDC5 and PNPLA3 Variants and the Risk of Hepatocellular Carcinoma in HCV-Infected Patients in Egypt

Journal of Bioscience and Applied Research
Article 9, Volume 10, Issue 6, December 2024, Pages 65-77    PDF (953.1 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2024.395621
Authors
Osama M. Roshdy1; Mai M. El-Daly2; Mohamed Gamal Mohamed3; Mohamed Abdel-Hamid; Mohamed I. Zanaty* 4
1Department of Molecular Biology, Nasser Institute for Research and Treatment, Ministry of Health, Cairo, Egypt/ Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt
2Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt
3Internal Medicine Department, Faculty of Medicine, Beni–Suef University, Beni–Suef, Egypt
4Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt
Abstract
Hepatocellular carcinoma (HCC) is the most prevalent and life-threatening form of liver cancer worldwide. In Egypt, HCC ranks as the second most common cancer in men and the sixth most common in women. This study investigated the association between DEPDC5 and PNPLA3 variants and the risk of developing HCC. One hundred HCC patients related to HCV infection and 100 healthy controls were enrolled. Single nucleotide polymorphisms (SNPs) for DEPDC5 (rs1012068) and PNPLA3 (rs738409) were analyzed using real-time PCR. The DEPDC5 variants were significantly associated with the development of HCC. Mutant and heterozygous genotypes of DEPDC5 were significantly associated with HCC (OR = 15.98 [95% CI: 5.53-46.13], p < 0.001; OR = 6.04 [95% CI: 3.08-11.84], p < 0.001, respectively). However, the PNPLA3 polymorphism was not associated with HCC risk. Nevertheless, the PNPLA3 SNP was significantly correlated with HCC in individuals with elevated AFP levels (p = 0.026). These findings suggest that the DEPDC5 could serve as an indicator for diagnosing the progression of liver diseases to HCC in HCV patients in Egypt. Additionally, PNPLA3 polymorphisms may play a role in the progression and severity of HCC, especially in cases with elevated AFP levels.
Keywords
HCC; HCV; DEPDC5; PNPLA3; Egypt
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