Study of αvß3 integrin gene expression in the endometrium of women with unexplained recurrent Spontaneous abortion | ||
| Journal of Bioscience and Applied Research | ||
| Volume 10, Issue 5, December 2024, Pages 63-67 PDF (1.01 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbaar.2024.395692 | ||
| Authors | ||
| Zahraa Ch. Hameed* ; Rusul Ali AL-Masaoodi; Maryam Hadi Jabbar; Zainab Abdul Kareem Abbas; Zahra H. AL-Wazni | ||
| College of Applied Medical Sciences /University of Kerbala, Iraq | ||
| Abstract | ||
| Background: In 50% of cases, the pathogenesis of unexplained recurrent Spontaneous abortion (URSA) is still unclear. ` We assess the αvbeta3 integrin gene expression in fertile and RSA-afflicted women. Methods: Endometrial tissues (biopsies) (30 samples) divided into 15 RSA cases and controls (15) healthy through menstrual cycle in the mid-luteal period. The period of data collection was March 2022–December 2023. The αvß3 gene expression was examined and in compression to fertile women using (qRT-PCR). Results: The relative gene expression of αvß3 integrin was significantly decreased (p-value < 0.05) in RSA women in compression to control subjects. The reduction of αvß3 integrin might have an essential role in the pathogenesis of RSA. Conclusion: Comparing women with unexplained RSA to controls, the expression of integrin was considerably lower. Our results highlight the necessity of additional molecular examination of the endometrial tissue in afflicted women. | ||
| Keywords | ||
| URSA; αvß3 integrin; endometrial biopsy | ||
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