Alpha Smooth Muscle Actin role in Androgenetic Alopecia Pathogenesis:

Salem, Rehab Mohammed; Abdel Khalik, Ghada Mohammed; Abdrabbou, Rasha Mahmoud; Ibrahim, Yasmin Ahmed

doi:10.21608/bjas.2024.338936.1538

	Alpha Smooth Muscle Actin role in Androgenetic Alopecia Pathogenesis:
Benha Journal of Applied Sciences
Article 4, Volume 9, Issue 11, November 2024, Page 53-58 PDF (367.89 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2024.338936.1538
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Authors
Rehab Mohammed Salem¹; Ghada Mohammed Abdel Khalik²; Rasha Mahmoud Abdrabbou³; Yasmin Ahmed Ibrahim ⁴
¹Assistant Professor of Dermatology, Venereology and Andrology Faculty of Medicine- Benha University
²Assistant Professor of Dermatology, Venereology and Andrology Faculty of Medicine - Benha University
³Assistant Professor of Pathology Faculty of Medicine - Benha University
⁴M.B.B.Ch. Faculty of Medicine - Zagazig University -2011
Abstract
Background: Up to 80% of men and 50% of women will have androgenetic alopecia (AGA) at some point in their lives, making it the most prevalent kind of hair loss. As a result of the actions of dehydrotestosterone (DHT), a testosterone metabolite, on androgen-sensitive hair follicles, the width, length, and color of affected hair gradually decrease in AGA. The arrector pili muscle is made up of fusiform cells that don't have cytoplasmic striations and have centralized, cigar-shaped nuclei. These muscles round the hair follicle in the bulge area and are linked to it at an acute angle. Research has shown that the dermal sheath of hair follicles in both rats and humans contains alpha smooth muscle-actin (α-SMA), however this protein is not found in the dermal papilla cells. In this post, we will take a look at the pathophysiology of androgenic alopecia and how Alpha Smooth Muscle Actinin plays a part in it. The loss of structural integrity in hair follicles might be one way that α-SMA contributes to AGA. In the vertex area of AGA patients, the expression of α-SMA is significantly reduced. In addition, compared to the occipital area, the vertex region of AGA patients shows considerably decreased α-SMA expression.
Keywords
Hair follicle; androgenetic alopecia (AGA); as well as alpha smooth muscle-actin (α-SMA)


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