Synthesis, characterization, antimicrobial activity and DFT studies of novel phthalazine-5,10-dione derivatives

Abuderbala, Mariam Y. A.; El-Banna, Mohamed G.; RIZK, SAMEH A; El-Naggar, Abeer M.; Hassan, A.M.A.

doi:10.21608/ejchem.2024.338104.10845

	Synthesis, characterization, antimicrobial activity and DFT studies of novel phthalazine-5,10-dione derivatives
Egyptian Journal of Chemistry
Volume 68, Issue 8, August 2025, Page 567-576 PDF (980.03 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.338104.10845
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Authors
Mariam Y. A. Abuderbala¹; Mohamed G. El-Banna¹; SAMEH A RIZK ²; Abeer M. El-Naggar³; A.M.A. Hassan ¹
¹Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt.
²department of chemistry faculty of science ain shams university
³Department of Chemistry, Faculty of Science, Ain Shams University, Abbassiya 11566, Cairo, Egypt
Abstract
1H-pyrazolo[1,2-b] phthalazine-5,10-dione derivatives (5a-j) were synthesized in good yields using microwave-ultrasonic techniques (MW/US) in an attempt to find possible antibacterial characteristics. They were then described using mass, FTIR, and 1H-NMR spectra data. These antimicrobial compounds were further evaluated against two fungus strains, C. albicans and A. fumigatus, as well as B. subtilis, B. sphaericus, S. aureus (+ ve strains), and P. aeruginosa. Streptomycin is a reference treatment, while amphotericin B is a common antibiotic having antibacterial and antifungal qualities. The antibacterial and antifungal properties of compounds 5b, 5c, 5e, 5i, and 5j were comparable to those of the reference or control molecule. Moreover, to support the energy gap, polarizability, and binding site interactions, a DFT investigation was conducted successively.
Keywords
Pyrazolo[1,2-b]phthalazine-5,10-dione; MCRs; Anti-microbial activity; DFT


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