EVALUATION OF THE ANTI-ADHESIVE EFFICACY OF GELATIN SPONGE AND ALGINATE SPONGE IN THE PREVENTION OF POST-SURGICAL INTRA-ABDOMINAL ADHESIONS | ||||
| Assiut Veterinary Medical Journal | ||||
| Volume 71, Issue 184, January 2025, Page 101-114 PDF (1.12 MB) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.2024.322977.1406 | ||||
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| Authors | ||||
AHMED ABDELRAHIEM SADEK  1; HAJAR EID2; KHALED RADAD3; AHMED FATHY AHMED 1
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| 1Department of Surgery, Anesthesiology, and Radiology, College of Veterinary Medicine, Assiut University, Assiut 71526, Egypt. | ||||
| 2Veterinarian and Post-Graduate Student, Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, Egypt. | ||||
| 3Department of Pathology and Clinical Pathology, College of Veterinary Medicine, Assiut University, Assiut 71526, Egypt. | ||||
| Abstract | ||||
| The occurrence of intra-abdominal adhesions after abdominal surgical interventions is considered an important issue in veterinary clinics. Although several adhesion-reducing agents were evoked to overcome the formation of such intra-abdominal adhesions, their effectiveness was still unsatisfactory. Hence, the present study assessed and compared the antiadhesive capability of gelatine and alginate sponges to minimize or prevent the formation of post-surgical intra-abdominal adhesions in a rabbit model. The cecal abrasion model was induced in animals and left untreated as control positive or treated with either intra-abdominal application of gelatine sponge (GS) or alginate sponge (AS). Clinical observation, gross appearance and histological evaluations were performed after 2 weeks of surgery. Grossly, the gelatine sponge enhanced the formation of intra-abdominal adhesions compared to the alginate sponge and control positive groups. Furthermore, both GS-treated and sham groups revealed no fibrosis on histological outcomes. The AS-treated group induced an extensive reaction with the formation of a marked degree of fibrosis and inflammatory cell infiltration. It was concluded that a gelatine sponge possesses the potential to prevent adhesions that could be formed intra-abdominally after abdominal surgery. An alginate sponge stimulates the formation of these adhesions. | ||||
| Keywords | ||||
| Intra-abdominal; adhesions; gelatine; alginate; anti-adhesion | ||||
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