Alleviating doxorubicin-induced neurotoxicity with roselle extract
Badr, N., El-deeb, M., Ali, M., Harera, S., Mokhtar, H., El-Gerbed, M. (2024). Alleviating doxorubicin-induced neurotoxicity with roselle extract. EKB Journal Management System, 2(2), 196-211. doi: 10.21608/bbj.2025.395978
Nada S Badr; Menna Allah A. El-deeb; Mustafa N. Ali; Shaimaa S. Harera; Haneen M. Mokhtar; Mohamed S.A. El-Gerbed. "Alleviating doxorubicin-induced neurotoxicity with roselle extract". EKB Journal Management System, 2, 2, 2024, 196-211. doi: 10.21608/bbj.2025.395978
Badr, N., El-deeb, M., Ali, M., Harera, S., Mokhtar, H., El-Gerbed, M. (2024). 'Alleviating doxorubicin-induced neurotoxicity with roselle extract', EKB Journal Management System, 2(2), pp. 196-211. doi: 10.21608/bbj.2025.395978
Badr, N., El-deeb, M., Ali, M., Harera, S., Mokhtar, H., El-Gerbed, M. Alleviating doxorubicin-induced neurotoxicity with roselle extract. EKB Journal Management System, 2024; 2(2): 196-211. doi: 10.21608/bbj.2025.395978

Alleviating doxorubicin-induced neurotoxicity with roselle extract

Biological and Biomedical Journal
Volume 2, Issue 2, July 2024, Page 196-211  XML PDF (1.82 MB)
Document Type: Original Article
DOI: 10.21608/bbj.2025.395978
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Authors
Nada S Badr email 1; Menna Allah A. El-deeb2; Mustafa N. Ali2; Shaimaa S. Harera2; Haneen M. Mokhtar2; Mohamed S.A. El-Gerbed2
1Cell biology, histology and genetics, Zoology Department, faculty of Science, Damanhur University
2Zoology Department, Faculty of Science, Damanhur University, Damanhur, Egypt
Abstract
Doxorubicin (DOX) is a potent chemotherapeutic drug used in cancer treatment, but it can lead to neurotoxicity particularly in the peripheral nervous system causing neuropathic pain. Roselle extract, known for its neuroprotective properties, has gained attention as a potential therapeutic agent in mitigating such neurotoxic effects. In this study investigated the neuroprotective potential of roselle water extract (RWE) against DOX-induced neurotoxicity in rats, focusing on the spinal cord, sciatic nerve, and neuropathic pain. Male albino rats were divided into four groups (6 rats/group); control, RWE-treated (500 mg/kg body weight/day; oral adminstration), DOX-treated (cumulative dose of 18 mg/kg body weight; intraperitoneal injected), and DOX + RWE-treated groups. Various assessments, including thermal nociception tests (hot plate, tail flicking, and cold plate), biochemical analysis of oxidative stress markers including malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), catalase (CAT) and histopathological evaluation of spinal cord and sciatic nerve tissues were conducted. DOX treatment led to increases in oxidative stress (↑MDA, ↑MPO, ↓SOD, and ↓CAT), neuronal damage, axonal demyelination, astrocytes number, and microglial cell activation, and a reduction in Schwann cell population. However, concurrent administration of RWE with DOX significantly reduced oxidative stress, preserved neuronal morphology, decreased glial cells activation, improved Schwann cell density, and attenuated neuropathic pain responses compared to the DOX-only treated rats. These findings suggested that RWE possessed antioxidant and neuroprotective properties, making it a potential complementary therapy to alleviate peripheral neuropathy associated with DOX treatment.
Keywords
Doxorubicin; Neurotoxicity; Roselle Extract; Spinal cord; Sciatic nerve
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