Prevalence of Candida species colonization in patients with chronic liver disease admitted to the intensive care unit: A prospective two center study

Hasan, Eman Medhat; El Serafy, Magdy Amin; Eletreby, Rasha; Shousha, Hend; Wassef, Mona Abdelaziz; Salem, Sherifa Tarek; Anwar, Rana Mostafa; Mostafa, Nermin Zaky; Elawady, Basma Ahmed

doi:10.21608/mid.2024.331260.2311

	Prevalence of Candida species colonization in patients with chronic liver disease admitted to the intensive care unit: A prospective two center study
Microbes and Infectious Diseases
Article 37, Volume 6, Issue 1, February 2025, Page 389-395 PDF (318.48 K)
Document Type: Original Article
DOI: 10.21608/mid.2024.331260.2311
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Authors
Eman Medhat Hasan¹; Magdy Amin El Serafy¹; Rasha Eletreby¹; Hend Shousha ¹; Mona Abdelaziz Wassef ²; Sherifa Tarek Salem ²; Rana Mostafa Anwar ³; Nermin Zaky Mostafa ⁴; Basma Ahmed Elawady ⁴
¹Department of Endemic Medicine and Hepatogastroenterology, Faculty of Medicine, Cairo University
²Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University
³Department of Hepatogastroenterology and Endoscopy, Agouza Police hospital
⁴Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
Abstract
Background: Due to their weakened immune systems, patients with chronic liver illness are more vulnerable to a variety of opportunistic fungal infections. Candida species are commonly isolated from patients admitted to hepatic intensive care unit (ICU). Aim: to detect the prevalence of Candida species colonization and their antifungal susceptibility in ICU patients with chronic liver disease. Methods: Two-center case control study was carried out from January2019 to June 2020 on 100 cirrhotic patients with chronic hepatitis C virus (HCV) admitted to hepatic ICU. Oral swabs and urine samples were cultured on CHROM agar followed by an automated VITEK 2 technique for identification of Candida species and antifungal susceptibility testing. Results: Candida albicans was the most prevalent Candida species in both urine (74%) and oral swab (66%) cultures using CHROM agar. The most prevalent candida species detected with an automated VITEK 2 technique was Candida albicans in both urine and oral swab cultures with higher resistance to fluconazole in isolates from urine and higher resistance to caspofungin in mouth swabs. Conclusion: Candida albicans is highly prevalent in cirrhotic patients admitted to the ICU with 3-4 times increased risk of colonization compared to controls with multiple antifungal drug resistance. Voriconazole has high efficacy against Candida species with low resistance and can be considered in critically ill patients to offer better survival. Strict follow up for critically ill cirrhotic patients admitted to ICUs for early diagnosis and treatment of fungal infections to offer better survival.
Keywords
Candida; colonization; hepatic dysfunction; antifungal resistance


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