Silymarin and Nano Silymarin alleviate the oxidative stress and damaged Histoarchitecture of the liver in Ehrlich Ascites carcinoma bearing mice. | ||||
| Minia Journal of Agricultural Research and Development | ||||
| Volume 44, Issue 4, December 2024, Page 653-669 PDF (491.45 K) | ||||
| Document Type: Original Articles | ||||
| DOI: 10.21608/mjard.2024.396003 | ||||
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| Abstract | ||||
| The ancient medicinal plant Silybum marianum has been used to cure various diseases for centuries. Silymarin is the main bioactive ingredient found in these plant seeds. Thus, the purpose of this study was to evaluate the ability of silymarin and nano silymarin to alleviate oxidative stress and ameliorate damaged histoarchitecture of the liver in Ehrlich ascites carcinoma-bearing mice. HPLC analysis of nano silymarin flavonoid compounds in milk thistle seed extract was performed. A total of 60 Swiss albino female mice were randomly separated into four equal groups. The first group was assigned as the normal control. An intraperitoneal injection of 2.5 x 10 6 EAC cells was administered to each of the three remaining groups. As the EAC positive control group, the second group didn't receive additional treatment. Mice in the third and fourth groups ingested orally Silymarine and nano silymarine at a dose of 100 mg/kg b.w. daily for 6 weeks. Markers of oxidative stress and tumors, as well as enzymatic and non- enzymatic antioxidants, were assessed in each experimental group. Furthermore, a liver histopathological examination was performed. The findings showed that mice with induced EAC had damaged liver histoarchitecture, low levels of enzymatic and non-enzymatic antioxidants, and high levels of tumor and oxidative stress markers. Administration of silymarine and nano silymarine to EAC-bearing mice reduced oxidative stress and improved the histoarchitecture of the damaged liver. | ||||
| Keywords | ||||
| EAC-bearing mice; Nano silymarin; oxidative stress; Silymarin | ||||
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