Does Serum vitamin D affect disease activity, sleep disorders and quality of life in Systemic Lupus Erythematosus patients?
EL-sharkawy, A., Gado, S., Ibrahim, W., EL-banna, H. (2024). Does Serum vitamin D affect disease activity, sleep disorders and quality of life in Systemic Lupus Erythematosus patients?. EKB Journal Management System, 29(2), 9-17. doi: 10.21608/kamj.2024.338437.1017
Amira Mohammad EL-sharkawy; Souzan Ezzat Gado; Wesam Salah Ibrahim; Hanaa Samy EL-banna. "Does Serum vitamin D affect disease activity, sleep disorders and quality of life in Systemic Lupus Erythematosus patients?". EKB Journal Management System, 29, 2, 2024, 9-17. doi: 10.21608/kamj.2024.338437.1017
EL-sharkawy, A., Gado, S., Ibrahim, W., EL-banna, H. (2024). 'Does Serum vitamin D affect disease activity, sleep disorders and quality of life in Systemic Lupus Erythematosus patients?', EKB Journal Management System, 29(2), pp. 9-17. doi: 10.21608/kamj.2024.338437.1017
EL-sharkawy, A., Gado, S., Ibrahim, W., EL-banna, H. Does Serum vitamin D affect disease activity, sleep disorders and quality of life in Systemic Lupus Erythematosus patients?. EKB Journal Management System, 2024; 29(2): 9-17. doi: 10.21608/kamj.2024.338437.1017

Does Serum vitamin D affect disease activity, sleep disorders and quality of life in Systemic Lupus Erythematosus patients?

Kasr Al Ainy Medical Journal
Volume 29, Issue 2, December 2024, Page 9-17  XML PDF (527.36 K)
Document Type: Original Article
DOI: 10.21608/kamj.2024.338437.1017
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Authors
Amira Mohammad EL-sharkawy1; Souzan Ezzat Gado email 2; Wesam Salah Ibrahim3; Hanaa Samy EL-banna4
1Lecturer Rheumatology, Rehabilitation & Physical Medicine. Faculty of Medicine, Tanta University, Tanta, Egypt
2Associate professor Rheumatology, Rehabilitation &Physical Medicine. Faculty of Medicine, Tanta university . Egypt
3Professor clinical pathology. Faculty of Medicine, Tanta University, Tanta, Egypt
4Associate professor Rheumatology, Rehabilitation & Physical Medicine. Faculty of Medicine, Tanta University, Tanta, Egypt
Abstract
Background: Early detection of vitamin D deficiency in patients with Systemic Lupus Erythematosus (SLE) may prevent or reduce fatigue, sleep and quality of daily life impairment.
Objectives: to assess vitamin D deficiency or insufficiency in SLE patients, and to correlate it with clinical disease activity, sleep and quality of life impairment.
Methods: 80 SLE patients plus 40 healthy volunteers as a control group. Sleep quality assessed by Pittsburgh Sleep Quality Index; disease activity assessed by SLE Disease Activity Index 2000. Functional capacity assessed by health assessment questionnaire. Serum Vit D measured by ELISA.
Results: Serum vitamin D (25-OH D) levels were significantly lower in SLE patients compared to controls (p = 0.02).  The lowest vitamin D level was detected in SLE patients with lupus nephritis (p = 0.003).
There was a significant difference in SLEDAI, PSQI, FACIT-F, HAQ and SLE-QoL scores between SLE patients with sufficient and insufficient/deficient vitamin D serum levels (p= 0.028, and 0.001).
a significant negative correlation between serum vitamin D level with clinical disease activity, functional capacity, sleep and quality of life.
Conclusion: Vitamin D may play an important role in the pathogenesis of SLE and could be a promising biomarker of SLE disease activity.
Keywords
Systemic Lupus Erythematosus; vitamin D; Sleep Quality Index (PSQI); vitamin D deficiency; Systemic Lupus Erythematosus Quality of Life (SLEQoL); Lupus nephritis
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