Comprehensive Insights into Psoriasis: Disease Types, Underlying Mechanisms, and Effective Treatments | ||||
| Records of Pharmaceutical and Biomedical Sciences | ||||
| Volume 8, Issue 1, 2024, Page 212-230 PDF (1.13 MB) | ||||
| Document Type: Mini-reviews | ||||
| DOI: 10.21608/rpbs.2024.338203.1338 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Menna Moustafa Eldawoudy  1; dalia shaalan abdelsalam2; maivel heshmat ghattas3; Noha M Mesbah4; Dina M Abo-Elmatty4; Eman T. Mehanna 5
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| 1Biochemistry, Faculty of pharmacy,horus university,damietta, Egypt | ||||
| 2Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||||
| 3Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Port said University, Port said, Egypt | ||||
| 4Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt | ||||
| 5Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt | ||||
| Abstract | ||||
| Psoriasis is a prevalent immune-mediated disorder characterized by inflammation of the skin and joints, impacting significant percentages of global populations. Psoriasis is inherited, and individuals' genetic backgrounds make some people more likely to get this illness. The prevalence of the disease is estimated to impact approximately 1–3% of the global population. However, psoriasis's prevalence exhibits variation among different populations owing to its genetic basis. Psoriasis is classified as a systemic illness due to the notable prevalence of comorbidities among affected individuals. These comorbidities include psoriatic arthritis, cardiovascular disease, metabolic syndrome, nonalcoholic fatty liver disease, inflammatory bowel disease, osteoporosis, and psychiatric disorders. Chronic plaque psoriasis, also referred to as psoriasis vulgaris (PV), is the prevailing form of psoriasis, constituting around 90% of the reported cases. Psoriasis was initially perceived as an illness primarily affecting epidermal keratinocytes, but it is now acknowledged as one of the most prevalent immune-mediated disorders. The pathophysiology of psoriasis is significantly influenced by tumor necrosis factor α, dendritic cells, and T cells. There are several treatment options available for psoriasis based on the disease severity. | ||||
| Keywords | ||||
| Keywords: Psoriasis; Psoriasis Vulgaris; pathophysiology; Treatment; Comorbidities | ||||
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