Schiff bases performance and challenge: Chemical synthesis and current state of biological activities | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 8, August 2025, Page 425-449 PDF (5.99 MB) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/ejchem.2024.333199.10741 | ||||
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| Authors | ||||
Sara S. Alammari1; Lotfi M. Aroua   1, 2, 3; Fahad M. Alminderej 1
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| 1Department of Chemistry, College of Science, Qassim University, Qassim, 51452, Kingdom of Saudi Arabia. | ||||
| 2Laboratory of (Bio)Organic, Structural and Polymer Chemistry (LR99ES14), Department of Chemistry, Faculty of Sciences of Tunis, Tunis El-Manar University, El-Manar, I 2092 Tunis, Tunisia. | ||||
| 3Carthage University, Faculty of Sciences of Bizerte, 7021 Jarzouna, Bizerte, Tunisia. | ||||
| Abstract | ||||
| Several structure incorporating Schiff bases found multiple applications in different field. Several therapeutic compounds in the anti-cancer, anti-hypertensive, anti-microbial, anti-fungal, and anti-ulcer segments have been produced using the moiety, which has become an essential anchor for the creation of novel pharmacologically active medicines. Since they are pharmacophoric and synthetically possible, Schiff bases have been actively sought after in the creation of novel derivatives and analogues. As a result, they have become one of the most sought-after and essential pharmacophores for drug development. A broad range of biological activities have been made possible by the different substituents and their varying patterns surrounding the Schiff base nucleus. Furthermore, theses moiety serves as a building block for the synthesis of several lead compounds, novel chemical entities, and therapeutic candidates. | ||||
| Keywords | ||||
| Synthesis; Schiff base; antibacterial activity; antioxidant; anticancer activity; antifungal; antimicrobial activity | ||||
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