Effect of isotretinoin treatment on Biotinidase level and depression degree in Acne Vulgaris Patients (Randomized control trail)
Raouf Hassan, A., Younis Elsary, A., atwa, O., Mahmoud, R., soltan, M., Ezzat, N. (2024). Effect of isotretinoin treatment on Biotinidase level and depression degree in Acne Vulgaris Patients (Randomized control trail). EKB Journal Management System, 14(2), 46-58. doi: 10.21608/fumj.2024.306794.1372
Amel Raouf Hassan; Asmaa Younis Elsary; omaymah ahmad atwa; Rania Hosny Mahmoud; mohamed ramadan soltan; Noha Ezzat. "Effect of isotretinoin treatment on Biotinidase level and depression degree in Acne Vulgaris Patients (Randomized control trail)". EKB Journal Management System, 14, 2, 2024, 46-58. doi: 10.21608/fumj.2024.306794.1372
Raouf Hassan, A., Younis Elsary, A., atwa, O., Mahmoud, R., soltan, M., Ezzat, N. (2024). 'Effect of isotretinoin treatment on Biotinidase level and depression degree in Acne Vulgaris Patients (Randomized control trail)', EKB Journal Management System, 14(2), pp. 46-58. doi: 10.21608/fumj.2024.306794.1372
Raouf Hassan, A., Younis Elsary, A., atwa, O., Mahmoud, R., soltan, M., Ezzat, N. Effect of isotretinoin treatment on Biotinidase level and depression degree in Acne Vulgaris Patients (Randomized control trail). EKB Journal Management System, 2024; 14(2): 46-58. doi: 10.21608/fumj.2024.306794.1372

Effect of isotretinoin treatment on Biotinidase level and depression degree in Acne Vulgaris Patients (Randomized control trail)

Fayoum University Medical Journal
Volume 14, Issue 2, December 2024, Page 46-58  XML PDF (598.32 K)
Document Type: Review Articles
DOI: 10.21608/fumj.2024.306794.1372
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Authors
Amel Raouf Hassan1; Asmaa Younis Elsary email 2; omaymah ahmad atwa1; Rania Hosny Mahmoud3; mohamed ramadan soltanorcid 4; Noha Ezzat1
1Dermatological and Venereology department, Faculty of Medicine-Fayoum University-Egypt
2Public health department-Faculty of Medicine - Fayoum University - Egypt
3Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum
4Psychiatry department , faculty of medicine , fayoum university- Egypt
Abstract
Background: Acne vulgaris is considered as a persistent inflammatory condition affecting the sebaceous follicles. The strongest inhibitor of sebum production is isotretinoin.. Isotretinoin treatment may cause acquired biotin deficiency by decrease biotinidase activity. The burden of severe acne may be reflected in depression and suicidal thoughts rather than being a side effect of isotretinoin drug. Aim: This work aims to assess the effects of isotertinoin on the biotinidase serum level in acne patients and to correlate these changes with depression and acne scores. Methods: Current study was a randomized control trial study. It included two arms; interventional arm and control arm. Each arm included 22 acne patients aged between 18 and 30 years. Interventional arm received isotertinoin treatment for two months. Level of biotinidase, depression and acne scores assessed before and after the intervention. Results: At baseline assessment, the interventional group showed no statistical significant difference in biotinidsa level, but show a significant higher level of depression score (16.27 ±9.93), versus (10±4.32) in control group with p-value 0.01.The interventional group showed high statistically significant decrease in biotinidase level from (1389.09±499.68) to (716.86±212.18) p-value <0.001 and increase in depression score from (16.27±9.93) to (24.59±12.11) p-value 0.007 after two months. Acne score showed a significant positive correlation with depression score after isotretinoin intake. Conclusion: When isotretinoin is used to treat acne, the biotindase level decreased and the depression score increased.
Keywords
Acne; Biotinidase; Depression; Isotretinoin
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