ALPHA1-ADRENERGIC RECEPTOR BLOCKING ACTION OF CARVEDILOL CONTRIBUTES TO TACKLING DEXAMETHASONE-INDUCED INSULIN RESISTANCE AND TO A LESSER EXTENT HEPATIC DAMAGE
Hafez, M., Ahmad, E., Mahmoud, M., Ibrahim, I. (2025). ALPHA1-ADRENERGIC RECEPTOR BLOCKING ACTION OF CARVEDILOL CONTRIBUTES TO TACKLING DEXAMETHASONE-INDUCED INSULIN RESISTANCE AND TO A LESSER EXTENT HEPATIC DAMAGE. EKB Journal Management System, 48(1), 681-696. doi: 10.21608/bfsa.2024.322563.2288
Mohamed Alaa Hafez; Enssaf Ahmad Ahmad; Mona Fouad Mahmoud; Islam Ahmed Ibrahim. "ALPHA1-ADRENERGIC RECEPTOR BLOCKING ACTION OF CARVEDILOL CONTRIBUTES TO TACKLING DEXAMETHASONE-INDUCED INSULIN RESISTANCE AND TO A LESSER EXTENT HEPATIC DAMAGE". EKB Journal Management System, 48, 1, 2025, 681-696. doi: 10.21608/bfsa.2024.322563.2288
Hafez, M., Ahmad, E., Mahmoud, M., Ibrahim, I. (2025). 'ALPHA1-ADRENERGIC RECEPTOR BLOCKING ACTION OF CARVEDILOL CONTRIBUTES TO TACKLING DEXAMETHASONE-INDUCED INSULIN RESISTANCE AND TO A LESSER EXTENT HEPATIC DAMAGE', EKB Journal Management System, 48(1), pp. 681-696. doi: 10.21608/bfsa.2024.322563.2288
Hafez, M., Ahmad, E., Mahmoud, M., Ibrahim, I. ALPHA1-ADRENERGIC RECEPTOR BLOCKING ACTION OF CARVEDILOL CONTRIBUTES TO TACKLING DEXAMETHASONE-INDUCED INSULIN RESISTANCE AND TO A LESSER EXTENT HEPATIC DAMAGE. EKB Journal Management System, 2025; 48(1): 681-696. doi: 10.21608/bfsa.2024.322563.2288

ALPHA1-ADRENERGIC RECEPTOR BLOCKING ACTION OF CARVEDILOL CONTRIBUTES TO TACKLING DEXAMETHASONE-INDUCED INSULIN RESISTANCE AND TO A LESSER EXTENT HEPATIC DAMAGE

Bulletin of Pharmaceutical Sciences Assiut University
Volume 48, Issue 1, June 2025, Page 681-696  XML PDF (946.96 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2024.322563.2288
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Authors
Mohamed Alaa Hafez email orcid 1; Enssaf Ahmad Ahmadorcid 2; Mona Fouad Mahmoud3; Islam Ahmed Ibrahim4
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
2Lecturer at Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt
3Professor at Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
4Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
Abstract
Insulin resistance is a well-established risk factor for serious health problems, including type 2 diabetes, cardiovascular disease, and stroke. Carvedilol has been documented to improve insulin sensitivity, ameliorate hyperlipidemia, and reduce the risk of diabetes. This study aimed to explore the role of α1-adrenergic receptors (α1ARs) in mediating the insulin-sensitizing effect of carvedilol in dexamethasone-treated rats. Insulin resistance was induced by subcutaneous injection of dexamethasone (10 mg/kg) for 7 days in rats. Five groups were used: control; dexamethasone; carvedilol (10 mg/kg); phenylephrine (1 mg/kg); carvedilol and phenylephrine. Serum glucose, insulin, and lipid profiles, as well as hepatic glycogen content, diacylglycerol level, protein kinase B activity, collagen type I, histopathological changes, and β-arrestin2 immunohistochemistry, were measured. The results demonstrated that blocking of α1- and β-ARs by carvedilol mitigated dexamethasone-induced insulin resistance and hepatic damage. Moreover, pre-injection of phenylephrine attenuated the insulin-sensitizing effect of carvedilol and, to a lesser extent, hepatic damage. In conclusion, the α1-blocking action of carvedilol contributes to its insulin-sensitizing effect as well as to its beneficial effect on the lipid profile. On the other hand, the hepatoprotective effect of carvedilol in dexamethasone-treated rats is less dependent on the α1AR.
Keywords
α1-adrenergic receptors; Carvedilol; Dexamethasone; Insulin resistance; Phenylephrine
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