IN VITRO SUSCEPTIBILITY OF GIARDIA LAMBLIA TO VONOPRAZAN | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 2, Volume 54, Issue 3, December 2024, Page 353-359 PDF (4.57 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2024.397249 | ||||
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| Authors | ||||
| ALAA F. SALLAM1; KHOLOUD A. EL-NOUBY2; HEND S. ABO SAFIA3; DINA I. ELGENDY1 | ||||
| 1Department of Medical Parasitology, Faculty of Medicine | ||||
| 2Department of Medical Parasitology, Faculty of Medicine | ||||
| 3Department of Pathology, Faculty of Medicine | ||||
| Abstract | ||||
| Vonoprazan (Vono) is used to manage duodenal and gastric ulcers, reflux esophagitis, and pre vention relapse. Its' a mechanism of action similar to proton pump inhibitors (PPIs), with a more rapid and prolonged acid-suppressive action, unaffected by diet and gene polymorphisms. This study assessed the therapeutic effect of Vono on Giardia lamblia in-vitro study as com pared with metronidazole (MTZ). The study used five cultures of 10ml of medium each and were divided into: Culture I: medium only (positive control), culture II: inoculated with 104 trophozo ites, culture III: inoculated with 104 trophozoites and treated with MTZ 50mg/ml, culture IV: in oculated with 104 trophozoites and treated with Vono 50µm/ml, and culture V: inoculated with 104 trophozoites and treated with the same of concentration both drugs. All cultures were subject ed to trophozoites count and scanning electron microscope study. The mean number of trophozo ites in all treated cultures: MTZ (MTZ), Vono, and combination cultures showed significantly de creased compared to positive control. The mean trophozoite counts in both Vono culture and combination culture were significantly lower than that in MTZ culture. Also, the mean trophozo ites count in combination culture was significantly lower than in Vono culture and MTZ culture. SEM showed marked destruction of trophozoites morphology in the combination group as con trasted to the positive control group. | ||||
| Keywords | ||||
| Vonoprazan; Metronidazole; Giardia Lamblia; In-vitro; RPMI media; SEM | ||||
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