THE DEVASTING EFFECTS OF PRAZIQUANTEL AND ALBENDAZOLE, ON CERCARIAE OFTHEDIGENEANPHANEROPSOLUS PRAOMIDIS (BAER, 1971) | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 7, Volume 54, Issue 3, December 2024, Page 401-406 PDF (4.03 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2024.397254 | ||||
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| Authors | ||||
| MOHAMMED E. ELZEINY; OLA A. SAMAK; SHEREEN A. FAHMY; ABDEL AZIZ A. KHIDR | ||||
| Department of Zoology, Faculty of Science, Damietta University, Egypt | ||||
| Abstract | ||||
| Phaneropsolidae is one of the digenean intestinal parasites of reptiles, birds, and mammals. To cease its life cycle, some cercariacidal drugs were used, such as praziquantel and albendazole. The intermediate host, a freshwater snail, Lanistes carinatus, was collected from Al-Inaniyyah village in the north-east of Damietta Governorate, Egypt. Phaneropsolus praomidis cercariae (xiphidiocercaria type) were harvested by exposing snails to strong artificial illumination. Lethal effect of both drugs, they were tested on the living cercariae of Phaneropsolus praomidis. The emerging cercariae were divided into three groups, the first group (group 1), which is the control group, contained 40 cercariae, the second group (group 2); and the third group (group 3) were to test the effect of praziquantel and albendazole, respectively, on the vitality of cercariae. The LC50 and LC95 of praziquantel against the present cercariae of Phaneropsolus in group 2 were 0.03 and 0.21 ppm, respectively. While in group 3, the LC50 and LC95 of albendazole were 0.87 and 2.7 ppm, respectively. Praziquantel has a more devasting effect against the treated cercariae of Phaneropsolus praomidis compared with albendazole. The ultrastructural changes using SEM that occurred on the tegumental surface of the treated cercariae with the two drugs were also observed compared to the untreated cercariae. The untreated cercariae have a pentagonal-shaped body with a long tail. In comparisons, cercariae treated with both drugs lost all healthy morphological features, but in varying degrees and effects between the two drugs. | ||||
| Keywords | ||||
| Phaneropsolus; xiphidiocercaria; Lanistes; praziquantel; albendazole | ||||
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