IMMUNOGLOBULIN E ROLE IN PARASITIC DISEASES: AN OVERVIEW | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 9, Volume 54, Issue 3, December 2024, Page 415-423 PDF (6.25 MB) | ||||
| DOI: 10.21608/jesp.2024.397256 | ||||
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| Authors | ||||
| SARYA MOHAMED HAWAM1; OSAMA SOBHY ZAKI2; TOSSON A. MORSY3 | ||||
| 1Consultant of Microbiology, Military Medical Academy, Cairo, 1129, Egypt | ||||
| 2Consultant of Preventive Medicine, Military Medical Academy, Cairo, 11291, Egypt | ||||
| 3Department of Parasitology, Faculty of Medicine, Ain- Shams University, Cairo, 11566, Egypt | ||||
| Abstract | ||||
| Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that is found only in mammals. IgE is synthesized by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, the ε chain containing four Igs-like constant do mains (Cε1-Cε4). IgE is an important part of the immune response against infection by cer tain zoonotic worms, and protozoa. IgE may have evolved as a defense to protect against ven oms. IgE also has an essential role in type I hypersensitivity, manifests in allergic diseases; al lergic asthma, most sinusitis types, allergic rhinitis, food allergies, and chronic urticar ia and atopic dermatitis specific types. IgE also plays a pivotal role in responses to allergens, such as anaphylactic reactions to drugs, bee stings, and antigen preparations used in desensiti zation immunotherapy. IgE is the least blood serum levels in a non-atopic individual are only 0.05% of Ig concentrat- ion compared to 75% for IgGs at 10mg/ml. But, it can trigger anaphylaxis, one of the most rap id and severe immunological reactions. This reviewed IgE role of in some zoonotic parasites. | ||||
| Keywords | ||||
| IgE; mammals; Helminthes; Protozoa; Overview | ||||
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