THERAPEUTIC EFFICACY OF ARTEMISIA JUDAICA EXTRACT LOADED ON SILVER NANOPARTICLES IN EXPERIMENTALLY INDUCED MURINE TRICHINELLOSIS | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 11, Volume 54, Issue 3, December 2024, Page 429-439 PDF (6.86 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2024.397258 | ||||
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| Authors | ||||
| MOSTAFA E. MOSTAFA1; MORSY R. M. GENEEDY2; AHMED M. A. MOHAMED2; FATMA M. EL-LESSY3 | ||||
| 1Departments of Parasitology, Faculty of Medicine Al-Azhar University, Damietta, Egypt | ||||
| 2Departments of Parasitology, Faculty of Medicine Al-Azhar University, Cairo, Egypt | ||||
| 3Departments of Parasitology, Faculty of Medicine Al-Azhar University, Cairo ,Egypt | ||||
| Abstract | ||||
| Benzimidazole derivatives are frequently used to treat trichinellosis. However, drug resistance, adverse effects, and low bioavailability restrict their therapeutic use in treating Trichinella infec tions. The need for a novel, secure and efficient anti-trichinellosis treatment is therefore impera tive. Artemisia judaica showed strong anthelmintic and antiprotozoal properties. The study eval uated the effectiveness of A. judaica extract compared with Albendazole alone or loaded on sil ver nanoparticles in trichinellosis infected mice. Mice were classified into 7 groups: GI: negative control, GII: positive control, GIII: infected treated with silver nanoparticles, GIV: infected treated with Artemisia judaica extract, GV: infected treated with albendazole, GVI: infected treated with Artemisia judaica extract loaded on silver nanoparticles and GVII: infected treated with albendazole loaded on silver nanoparticles. They were equally divided into two subgroups based on euthanasia time at 7th & 35th days post infection. Parasitological, immun- ological, and histopathological analyses were carried out to assess the efficacy of the treatment. Artemisia ju daica extract loaded on silver nanoparticles treated mice induced a significant reduction in mean number of T. spiralis adults and larvae in infected mice, restored normal intestinal structure, and reduced pathogenic impact of infection by a significant decrease in GPx and SOD activities and immunomodulation of proinflammatory (TNF-α) and anti-inflammatory (IL-6, IL-10) cytokines. They may be useful as prospective trichinellosis treatment. | ||||
| Keywords | ||||
| Artemisia judaica; Albendazole; Silver nanoparticles; Cytokines; Trichinellosis | ||||
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