ASSOCIATION OF IP6K3 GENE SNP rs791903 AND HASHIMOTO’S THYROIDITIS IN A COHORT OF EGYPTIAN PATIENTS
Marzouk, S., Nassar, E., El-Sherbiny, T., Bachu, H. (2024). ASSOCIATION OF IP6K3 GENE SNP rs791903 AND HASHIMOTO’S THYROIDITIS IN A COHORT OF EGYPTIAN PATIENTS. EKB Journal Management System, 6(4), 86-87. doi: 10.21608/alexpo.2024.344592.2032
Salah Ahmed Marzouk; Eman Saad Nassar; Tamer Mohamed Abdelhamid El-Sherbiny; Hassan Ahmed Bachu. "ASSOCIATION OF IP6K3 GENE SNP rs791903 AND HASHIMOTO’S THYROIDITIS IN A COHORT OF EGYPTIAN PATIENTS". EKB Journal Management System, 6, 4, 2024, 86-87. doi: 10.21608/alexpo.2024.344592.2032
Marzouk, S., Nassar, E., El-Sherbiny, T., Bachu, H. (2024). 'ASSOCIATION OF IP6K3 GENE SNP rs791903 AND HASHIMOTO’S THYROIDITIS IN A COHORT OF EGYPTIAN PATIENTS', EKB Journal Management System, 6(4), pp. 86-87. doi: 10.21608/alexpo.2024.344592.2032
Marzouk, S., Nassar, E., El-Sherbiny, T., Bachu, H. ASSOCIATION OF IP6K3 GENE SNP rs791903 AND HASHIMOTO’S THYROIDITIS IN A COHORT OF EGYPTIAN PATIENTS. EKB Journal Management System, 2024; 6(4): 86-87. doi: 10.21608/alexpo.2024.344592.2032

ASSOCIATION OF IP6K3 GENE SNP rs791903 AND HASHIMOTO’S THYROIDITIS IN A COHORT OF EGYPTIAN PATIENTS

ALEXMED ePosters
Article 1, Volume 6, Issue 4, September 2024, Pages 86-87
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2024.344592.2032
Authors
Salah Ahmed Marzouk1; Eman Saad Nassar2; Tamer Mohamed Abdelhamid El-Sherbiny3; Hassan Ahmed Bachu* 1
1Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University
2Department of Clinical and Chemical Pathology3, Faculty of Medicine, Alexandria University
3Department of Internal Medicine, Faculty of Medicine, Alexandria University
Abstract
Introduction :
Hashimoto’s thyroiditis (HT) is an autoimmune thyroid disorder (AITD) characterized by chronic lymphocytes infiltration and proliferation in the thyroid gland resulting in progressive damage of the gland with release of thyroid peroxidase and thyroglobulin immunoglobulin. Etiology of HT is multifactorial and still unclear. However, the probability of developing HT has both environmental and genetic influence with the latter been more prominent. The study on pathogenetic mechanics has revealed various genes involved in development of HT, such as those coding the Human Leukocyte Antigen (HLA) complex; commonly, HLA-B* 46:01, HLA-A* 02:07 and HLA-DRB4. There is emerging evidence on the role of single nucleotide polymorphisms (SNPs) in the predisposition to HT. A genome-wide association study (GWAS) done on Croatian population found rs791903 inside inositol hexakisphosphate kinase 3 (IP6K3) gene as a candidate for HT predisposition in caucasian population. There exist a few studies done on this gene in other nationalities besides Caucasians.

Aim of the Study:
The aim of this study is to investigate the association of IP6K3 gene SNPs variant rs791903 in Hashimoto’s thyroiditis in a cohort of Egyptian subjects.
Keywords
Hashimoto’s thyroiditis (HT); IP6K3 GENE SNP rs791903; SNPs variant rs791903
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