Pathophysiology of Insulin Resistance and Related Skin Diseases ( Review Article) | ||||
| Sohag Medical Journal | ||||
| Volume 29, Issue 1., 2025, Page 16-23 PDF (960.96 K) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/smj.2024.331502.1504 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Asmaa Rafat Lotfy  1; doaa gaberabdelbaset2; esraa salah ismail3; Mary Atef Shokry4; Amira Ahmed Genedy 5
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| 1physiology department faculty of medicine sohag university | ||||
| 2Lecturer in Dermatology, venereology and andrology Department | ||||
| 3Dermatology, venereology and andrology Department , Faculty of medicine, Sohag University. | ||||
| 4Physiology department, Faculty of Medicine, Sohag university | ||||
| 5Medical Biochemistry, faculty of medicine, sohag university, sohag, Egypt | ||||
| Abstract | ||||
| Insulin resistance is a condition characterized by decreased sensitivity of insulin-targeting tissues to elevated physiological hormone levels. The liver secretes glucose into the blood during a fast in order to sustain euglycemia and supply energy to tissues that require glucose. Insulin released by pancreatic β-cells stimulates anabolism and inhibits catabolic processes following food consumption. Insulin resistance may be due to inherited, acquired, and mixed causes. Skeletal muscle, the liver, and adipose tissue are the three main locations of insulin resistance. Up to 70% of tissue glucose absorption occurs in muscle, Energy substrates must be processed by the liver. lipolysis is insulin-sensitive. Moreover, insulin plays a critical role in skin physiology and homeostasis, while its precise involvement in insulin signaling is still up for debate. In a healthy state, insulin controls the balance between keratinocyte proliferation and differentiation, which is necessary for the development of the epidermal structure. High levels of proinflammatory cytokines stimulate p38 Mitogen activated protein kinases in chronic inflammatory diseases (e.g., acne or psoriasis). | ||||
| Keywords | ||||
| Insulin; inflammation; Androgenetic alopecia; Acanthosis nigricans; psoriasis | ||||
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