Retrospective study of efficiency of Corticosteroids and Anticoagulants in Management of COVID 19 Patients with different comorbidities | ||
| Kasr Al Ainy Medical Journal | ||
| Volume 29, Issue 2, December 2024, Pages 19-30 PDF (657.86 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/kamj.2024.326284.1015 | ||
| Authors | ||
| Mahmoud F Nasser1; Mona Osman2; Mohamed Saad3; Ghada farouk Soliman* 4 | ||
| 1Demonstrator of Medical Pharmacology Department, Armed Forces College of Medicine | ||
| 2Professor of Medical Pharmacology Department, Faculty of medicine, Cairo University | ||
| 3Lecturer of Chest Department, Armed Forces College of Medicine | ||
| 4Assistant Professor of Medical Pharmacology Department, Faculty of medicine, Cairo University, Armed Forces College of Medicine | ||
| Abstract | ||
| Background: Human coronaviruses are one of the principle causes of upper respiratory infections, which were defined for the first time in 1962. A systemic inflammation that includes cytokine storm and thrombosis formation is the underlying cause of severe cases of COVID-19 patients that lead to multi-organ dysfunction.Aim: To assess the beneficial effect of corticosteroids and anticoagulants in treatment of COVID-19 in diabetic and hypertensive patients who were associated with other co-morbidities of chronic diseases or not, in addition to determination of the role of the anti-inflammatory markers in the prognosis of the disease and their correlation with CT imaging. Patients and methods: The study was conducted in the chest Department, Kobry El Kobba Military Hospital on 110 patients who were diagnosed with moderate and severe COVID-19. Results: Treatment with corticosteroids and anticoagulants decreased significantly the duration of hospital admission, need for oxygen in the survived treated patients compared to non-survived patients in addition to decline in the inflammatory markers (CRP, IL-6, D-dimer) especially Il6 which was the most prognostic test in all groups regardless the associated morbidity. This was correlated with CT imaging scoring. Conclusion: The early administration of corticosteroids and anticoagulants to severe COVID-19 pneumonic cases reduced the negative impacts in all group of patients regardless the associated morbidity or chronic diseases. Mortality was mainly increased in patients with older age, co-morbidity, worse CT findings, a higher oxygen therapy requirement, and a longer duration of hospitalization. IL-6 level after treatment has the best prognostic accuracy, followed by D-dimer level. Key Words: Corticosteroids, Anticoagulants, COVID 19. Background: Human coronaviruses are one of the principle causes of upper respiratory infections, which were defined for the first time in 1962. A systemic inflammation that includes cytokine storm and thrombosis formation is the underlying cause of severe cases of COVID-19 patients that lead to multi-organ dysfunction.Aim: To assess the beneficial effect of corticosteroids and anticoagulants in treatment of COVID-19 in diabetic and hypertensive patients who were associated with other co-morbidities of chronic diseases or not, in addition to determination of the role of the anti-inflammatory markers in the prognosis of the disease and their correlation with CT imaging. Patients and methods: The study was conducted in the chest Department, Kobry El Kobba Military Hospital on 110 patients who were diagnosed with moderate and severe COVID-19. Results: Treatment with corticosteroids and anticoagulants decreased significantly the duration of hospital admission, need for oxygen in the survived treated patients compared to non-survived patients in addition to decline in the inflammatory markers (CRP, IL-6, D-dimer) especially Il6 which was the most prognostic test in all groups regardless the associated morbidity. This was correlated with CT imaging scoring. Conclusion: The early administration of corticosteroids and anticoagulants to severe COVID-19 pneumonic cases reduced the negative impacts in all group of patients regardless the associated morbidity or chronic diseases. Mortality was mainly increased in patients with older age, co-morbidity, worse CT findings, a higher oxygen therapy requirement, and a longer duration of hospitalization. IL-6 level after treatment has the best prognostic accuracy, followed by D-dimer level. | ||
| Keywords | ||
| Corticosteroids; Anticoagulants; COVID 19 | ||
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