The Bio Adhesive Property of Some Saudi Herbal Plants Extracts in Wound Healing in Rats | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 8, August 2025, Pages 319-327 PDF (335.22 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2024.330201.10672 | ||
| Authors | ||
| Taha A. Kumosani1, 2, 3; Abeer Alnefayee1; Elie Barbour2, 3; Mohammed Qari4; Tarek Ahmed5, 6; Said S. Moselhy* 7 | ||
| 1Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia | ||
| 2Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University , Jeddah, Saudi Arabia | ||
| 3Production of Bio-products for Industrial Application Research Group, King Abdulaziz University, Jeddah, , Saudi Arabia | ||
| 4Hematology Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia | ||
| 5Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia | ||
| 6Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt | ||
| 7Biochemistry Department, Faculty of Science,Ain Shams University, Cairo, Egypt | ||
| Abstract | ||
| Saudi Arabia charaecterized in Arabian region with valuable flora medicinal plants. In the current study, we investigated the active ingerdeints and potential of methanol extracts of Walnut leaves (WL), Flaxseed (FL) Chamomile (CH), Arnica (AR) , Sage (SG) and Evening primrose (EP). as antioxidant, antibacterial and wound healing effeacy in rats. In current study, the highest inhibitory effect of IC50 against protein denaturation was detected for ER. Anti-inflammatory activity obtained half maximal inhibitory concentration (IC50) of various plant extracts with a different solvent. The average of zones of inhibition of sage and evening primrose with zone 20 at 200mg/0.5ml had very high significant differences compared to positive control whereas they do not have inhibition zones at concentration 5mg/0.5ml. The walnut, flaxseed, chamomile and arnica at different concentration have no inhibition zones against MRSA. Data obtained showed that, a significant decreased in the levels of hydroxyproline (p<0.001) content , reduced glutathione(p<0.01) , MPO (p<0.01) and EGF-beta (p<0.001) in diabetic rats compared with normal control. Diabetic rats treated with either extracts of Walnut leaves (WL), Flaxseed (FL), Chamomile (CH), Sage (SA), Arnica (AR), Evening primrose (ER) showed improvement in these parameters compared with untreated (p<0.001). But the ER is the most potent than other extract. It was concluded that Sage (SG) showed antimicrobial against MERSA at high concentrations compared with other extracts. The WL demonstrated the maximum one. While Evening primrose showed potent inflammatory effect and potent wound healing in diabetic rats. | ||
| Keywords | ||
| Anti; inflammatory; Antioxidant; wound healing; herbal Saudi | ||
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