Preliminary Study of Pasteurella Multocida: Isolation, Characterization, And Antibiotic Susceptibility in Egypt

Abdelrahman, Nada Abdelshafy; Eltarabili, Reham M.; Youssef, Fatma Mohamed; Enany, Mohamed Elsayed

doi:10.21608/scvmj.2024.397924

	Preliminary Study of Pasteurella Multocida: Isolation, Characterization, And Antibiotic Susceptibility in Egypt
Suez Canal Veterinary Medical Journal. SCVMJ
Article 77, Volume 29, Issue 2, December 2024, Page 449-461 PDF (1.28 MB)
Document Type: Original Article
DOI: 10.21608/scvmj.2024.397924
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Authors
Nada Abdelshafy Abdelrahman^* ¹; Reham M. Eltarabili²; Fatma Mohamed Youssef³; Mohamed Elsayed Enany²
¹Free Veterinarian
²Department of Bacteriology, Immunology, and Mycology, Faculty of Veterinary Medicine, Suez Canal University
³Animal Health Research Institute, Ismailia
Abstract
Pasteurella multocida is a Gram-negative, non-motile, capsulated bacterium of the Pasteurellaceae family, commonly found in the respiratory tracts of healthy animals but capable of becoming pathogenic under stress. This bacterium is a primary cause of pasteurellosis, a significant respiratory disease affecting many hosts, particularly poultry. It has led to substantial economic losses in regions like Egypt. In poultry, P. multocida infections cause respiratory distress and reduced egg production and growth rates, with serogroup A strains identified as the primary agents of fowl cholera (FC), an acute septicemic disease marked by high morbidity and mortality. The rapid spread of FC in poultry necessitates strict biosecurity to prevent transmission to other susceptible species. Traditional identification methods for P. multocida rely on morphological and biochemical. Seven P. multocida isolates were identified from 75 samples with a prevalence of 9.3%. All isolates were multidrug-resistant (MDR). Besides, all isolates were resistant to erythromycin, tylosin, penicillin, and oxytetracycline, followed by trimethoprim/sulfamethoxazole (50%). While recovered isolates were sensitive to chloramphenicol, the P. multocida control is effectively based on good management practices and antibiotic treatments. However, the overuse of antibiotics in veterinary settings has contributed to the emergence of multidrug-resistant (MDR) P. multocida strains, complicating treatment efforts. This study concluded that MDR P. multocida is significant in public health issues.
Keywords
Pasteurella multocida; Fowl cholera; Antibiotic susceptibility; Bacterial pathogenesis


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