Evaluation of Napsin A and CK5/6 Expression in Non-Small Cell Lung Carcinoma (NSCLC): An Immunohistochemical Study | ||||
| Benha Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 20 December 2024 PDF (590.99 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2024.304892.2132 | ||||
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| Authors | ||||
Nehal Saad Zafer1; Ranih Zakaria Amer2; Amr Farag El sebaei3; Omnia Yousef Bassyoni2; Hasan Ahmed Alrefaey  4
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| 1Professor of Pathology, Faculty of Medicine, Benha University | ||||
| 2Assistant Professor of Pathology, Faculty of Medicine, Benha University | ||||
| 3Assistant Professor of Pathology, Military Academy of Medicine | ||||
| 4Department of Pathology Faculty of Medicine-Benha University | ||||
| Abstract | ||||
| Background: Lung cancer is the most common type of cancer and the principal cause of death from cancer worldwide. This study aimed to evaluate the expression of Napsin A and CK5/6 in NSCLC, correlate immunohistochemical results of Napsin A and CK5/6 in differentiating between adenocarcinoma and SCC of the lung. assessment of the expression pattern of Napsin A and CK 5/6 as regard the available clinicopathological data available. Methods: This retrospective study was carried upon 40 lung cases; included 26 adenocarcinoma cases (Resection) and 14 cases of squamous cell carcinoma (Including 7 resection cases and 7 bronchoscopic biopsy cases). Results: Highly significant increase in CK5/6 score and expression, in SSC group; compared to ADC group (p < 0.001). ADC had a highly significant positive correlation with Napsin A score (p < 0.01). In the current study Pearson’s correlation analysis shows that; SSC, had a highly significant positive correlation with CK5/6 score. Conclusion: From our findings we can conclude that Napsin A score can predicted patients with ADC from patients with SSC. the increase in SSC histology; had an independent effect on increasing the probability of CK5/6 expression. the decrease in LN; had an independent effect on increasing the probability of Napsin A expression. | ||||
| Keywords | ||||
| Napsin A; CK5/6; NSCLC; Immunohistochemical | ||||
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