Evaluation Effects of Nebulized Hypertonic Saline and Nebulized Corticosteroids in Patients with Acute Respiratory Distress Syndrome
Wageh Mahdy, E., Ibrahim Saad, S., Abdelkawy Elznati, M., Reda Ahmed, R. (2025). Evaluation Effects of Nebulized Hypertonic Saline and Nebulized Corticosteroids in Patients with Acute Respiratory Distress Syndrome. EKB Journal Management System, 42(1), 263-279. doi: 10.21608/bmfj.2024.315656.2180
Enas Wageh Mahdy; Saad Ibrahim Saad; Mostafa Abdelkawy Elznati; Randa Reda Ahmed. "Evaluation Effects of Nebulized Hypertonic Saline and Nebulized Corticosteroids in Patients with Acute Respiratory Distress Syndrome". EKB Journal Management System, 42, 1, 2025, 263-279. doi: 10.21608/bmfj.2024.315656.2180
Wageh Mahdy, E., Ibrahim Saad, S., Abdelkawy Elznati, M., Reda Ahmed, R. (2025). 'Evaluation Effects of Nebulized Hypertonic Saline and Nebulized Corticosteroids in Patients with Acute Respiratory Distress Syndrome', EKB Journal Management System, 42(1), pp. 263-279. doi: 10.21608/bmfj.2024.315656.2180
Wageh Mahdy, E., Ibrahim Saad, S., Abdelkawy Elznati, M., Reda Ahmed, R. Evaluation Effects of Nebulized Hypertonic Saline and Nebulized Corticosteroids in Patients with Acute Respiratory Distress Syndrome. EKB Journal Management System, 2025; 42(1): 263-279. doi: 10.21608/bmfj.2024.315656.2180

Evaluation Effects of Nebulized Hypertonic Saline and Nebulized Corticosteroids in Patients with Acute Respiratory Distress Syndrome

Benha Medical Journal
Article 26, Volume 42, Issue 1, January 2025, Page 263-279  XML PDF (890.13 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2024.315656.2180
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Authors
Enas Wageh Mahdy1; Saad Ibrahim Saad2; Mostafa Abdelkawy Elznati email 3; Randa Reda Ahmed4
1Assistant Professor of Anaesthesiology and Intensive Care, Faculty of Medicine, Benha University, Egypt
2Professor of Anaesthesiology and Intensive Care, Faculty of Medicine, Benha University, Egypt
3M.B.B.Ch, Faculty of Medicine, Benha University, Egypt
4Lecturer of Critical Care Medicine, Faculty of Medicine, Benha University, Egypt
Abstract
Background: Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute respiratory failure as a result of diffuse lung inflammation and oedema manifested by hypoxemia and stiffness in the lungs. This study aimed to assess the efficacy of each of nebulized hypertonic saline and nebulized budesonide in improving respiratory mechanics, hypoxic index (PaO2/ FiO2), LIS (Murray score), mortality, duration of intensive care unit, and mechanical ventilation days in acute respiratory distress syndrome patients. Methods: This randomized, double-blind, placebo-controlled study was conducted on 90 patients with ARDS. Patients were randomly assigned into 3 equal groups: group I: received standard ICU ARDS care and nebulized hypertonic saline 3% (5ml) /12hr, Group II: received standard ICU ARDS care and nebulized corticosteroids/12hr and Group III: received standard ICU ARDS care and normal saline 0.9% (5ml) nebulizer /12hr as a placebo. Results: Regarding the outcome, ICU stay and MV duration were significantly shorter in group II compared to group I and III (P
Keywords
Nebulized; Hypertonic Saline; Corticosteroids; Acute Respiratory Distress Syndrome
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