Synthesis, Docking and Cytotoxicity Evaluation of 3-indolyl heterocycles as Potential Anti-Cancer Agents | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 8, August 2025, Pages 227-239 PDF (1.78 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2024.335435.10777 | ||
| Authors | ||
| Naglaa Fathy Radwan* 1; Elham darwish2; abdellatif abdellatif3 | ||
| 1Chemistry, Science, Cairo University | ||
| 2Cairo University, faculty of science, chemistry department | ||
| 3Cairo university, faculty of science, chemistry department | ||
| Abstract | ||
| 5´-cyanomeridianine G analogues produce from 3-cyanoacetyl indole accomplished in to steps by treatment with a mixture ofpiperidine andtriethylorthoformate in DMF and then cyclization of the resulting enaminonitrile with guanidine and thiourea are described. The biological evaluation against a range of cancer cells lines showed that indolylpyrimidinethione6was more cytotoxic against Lung carcinoma cell line (A549) with inhaibition activity of 95.4 % and it has the highst antioxidant activities. While the cyanomeridianine G 5 showed high cytotoxic activity against MCF7, A549 and HCT116 with 100, 88.6 and 74.6 % inhibition in cell viability, respectively. | ||
| Keywords | ||
| Enaminonitrile, Meridianines; indole alkaloids; biological activities,docking | ||
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