Synthesis, Docking and Cytotoxicity Evaluation of 3- heterocycles as Potential Anti-Cancer Agents | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 8, August 2025, Page 227-239 PDF (1.77 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.335435.10777 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Naglaa Fathy Radwan  1; Elham darwish2; abdellatif abdellatif3
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| 1Chemistry, Science, Cairo University | ||||
| 2Cairo University, faculty of science, chemistry department | ||||
| 3Cairo university, faculty of science, chemistry department | ||||
| Abstract | ||||
| 5´-cyanomeridianine G analogues produce from 3-cyanoacetyl indole accomplished in to steps by treatment with a mixture ofpiperidine andtriethylorthoformate in DMF and then cyclization of the resulting enaminonitrile with guanidine and thiourea are described. The biological evaluation against a range of cancer cells lines showed that indolylpyrimidinethione6was more cytotoxic against Lung carcinoma cell line (A549) with inhaibition activity of 95.4 % and it has the highst antioxidant activities. While the cyanomeridianine G 5 showed high cytotoxic activity against MCF7, A549 and HCT116 with 100, 88.6 and 74.6 % inhibition in cell viability, respectively. | ||||
| Keywords | ||||
| Enaminonitrile, Meridianines; indole alkaloids; biological activities,docking | ||||
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