Insights into Gut Microbiota and Pancreatic Cancer: A Review
El Morsi, R., AL Shafie, S., A. El Ashry, S., . EL Naggar, S., Bedair, S., Dehina, S., Kamal, S., El Hadidy, M., El Henidy, M., El Nagdy, N., El Hawary, Y., Gomaa, H., Khalifa, R., Yosef, E., Goda, R., Ramadan, H., Soliman, W., Abd El-Salam, M., Al-Madboly, L. (2024). Insights into Gut Microbiota and Pancreatic Cancer: A Review. EKB Journal Management System, 7(2), 1-16. doi: 10.21608/dusj.2024.294000.1070
Rasha Medhat El Morsi; Sohila H. AL Shafie; Sara A. El Ashry; Sara S . EL Naggar; Sara E Bedair; Shrouq N Dehina; Shokran A. Kamal; Mai H. El Hadidy; Menna H. El Henidy; Nada A. El Nagdy; Yasmin H. El Hawary; Hana A. Gomaa; Reham M. Khalifa; Esraa M. Yosef; Reham M. Goda; Heba Adel Ramadan; Wafaa E. Soliman; Mohamed Abd El-Salam; Lamiaa Al-Madboly. "Insights into Gut Microbiota and Pancreatic Cancer: A Review". EKB Journal Management System, 7, 2, 2024, 1-16. doi: 10.21608/dusj.2024.294000.1070
El Morsi, R., AL Shafie, S., A. El Ashry, S., . EL Naggar, S., Bedair, S., Dehina, S., Kamal, S., El Hadidy, M., El Henidy, M., El Nagdy, N., El Hawary, Y., Gomaa, H., Khalifa, R., Yosef, E., Goda, R., Ramadan, H., Soliman, W., Abd El-Salam, M., Al-Madboly, L. (2024). 'Insights into Gut Microbiota and Pancreatic Cancer: A Review', EKB Journal Management System, 7(2), pp. 1-16. doi: 10.21608/dusj.2024.294000.1070
El Morsi, R., AL Shafie, S., A. El Ashry, S., . EL Naggar, S., Bedair, S., Dehina, S., Kamal, S., El Hadidy, M., El Henidy, M., El Nagdy, N., El Hawary, Y., Gomaa, H., Khalifa, R., Yosef, E., Goda, R., Ramadan, H., Soliman, W., Abd El-Salam, M., Al-Madboly, L. Insights into Gut Microbiota and Pancreatic Cancer: A Review. EKB Journal Management System, 2024; 7(2): 1-16. doi: 10.21608/dusj.2024.294000.1070

Insights into Gut Microbiota and Pancreatic Cancer: A Review

Delta University Scientific Journal
Volume 7, Issue 2, September 2024, Page 1-16  XML PDF (531.3 K)
Document Type: Review articles
DOI: 10.21608/dusj.2024.294000.1070
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Authors
Rasha Medhat El Morsi email 1; Sohila H. AL Shafie2; Sara A. El Ashry2; Sara S . EL Naggar2; Sara E Bedair2; Shrouq N Dehina2; Shokran A. Kamal2; Mai H. El Hadidy2; Menna H. El Henidy2; Nada A. El Nagdy2; Yasmin H. El Hawary2; Hana A. Gomaa2; Reham M. Khalifa2; Esraa M. Yosef2; Reham M. Goda3; Heba Adel Ramadan3; Wafaa E. Soliman4; Mohamed Abd El-Salam5; Lamiaa Al-Madboly6
1Department of Microbiology & Immunology, Faculty of Pharmacy, Delta University For science and Technology, Gamsa, Egypt
21Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt
3Department of Microbiology & Immunology, Faculty of Pharmacy, Delta University For science and Technology, Gamsa, Egypt
42Department of Microbiology & Immunology, Faculty of Pharmacy, Delta University For science and Technology, Gamsa, Egypt 5Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, AL AHSA 31982, Kingdom
53Department of Pharmacognosy, Faculty of pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt
64Department of Microbiology & Immunology, Faculty of Pharmacy, Tanta University, Tanta, Egypt
Abstract
Pancreatic cancer is one of the major causes of cancer-related death worldwide and has a poor prognosis as pancreatic cancer usually shows little or no symptoms until it has advanced and spread. Therefore, most cases (up to 80 percent) are diagnosed at later, more difficult-to-treat stages. Currently, treatment relies on surgical resection and adjuvant therapies. Recent advances in biomedical research have highlighted the potential role of gut microbiota in the pathogenesis and progression of various cancers, including pancreatic cancer. The gut microbiota plays a crucial role in metabolism and immunomodulation. Emerging evidence suggests that the gut microbiota influences the metabolism of chemotherapeutic drugs and the tumor microenvironment, potentially affecting the efficacy of chemotherapy and immunotherapy for pancreatic cancer. In this review, we discuss the key connections between pancreatic cancer, the gut microbiota, and therapeutic effectiveness. We also highlight the promising potential of modifying the gut microbiota to enhance clinical outcomes for pancreatic cancer.



Keywords: Gut microbiota; Pancreatic cancer; Chemotherapy; Immunotherapy
Keywords
Gut microbiota; Pancreatic cancer; Chemotherapy; Immunotherapy
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