Combatting antimicrobial resistance: Mechanisms, emerging therapies, and future directions

Abdelshafey, Hebetullah ELsayed; Abdalla, Mozan Ali; Eltayeb, Enas Ezzeldein; Mohmmed, Rafa Omer; Younis, Alaa Abdelwahab; Musa, Yusra Ahmed Musa Ahmed; Shekedrees, Ebaa Iyad; Madani, Israa Abdalgader; Eltayeb, Omnia Abdullah; El-Maradny, Yousra A.

doi:10.21608/mb.2024.400342

	Combatting antimicrobial resistance: Mechanisms, emerging therapies, and future directions
Microbial Biosystems
Reviewers, Volume 9, Issue 2, December 2024, Page 96-114 PDF (1.05 MB)
DOI: 10.21608/mb.2024.400342
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Authors
Hebetullah ELsayed Abdelshafey¹; Mozan Ali Abdalla¹^{, 2}; Enas Ezzeldein Eltayeb¹^{, 2}; Rafa Omer Mohmmed¹^{, 2}; Alaa Abdelwahab Younis¹^{, 2}; Yusra Ahmed Musa Ahmed Musa¹^{, 2}; Ebaa Iyad Shekedrees¹^{, 2}; Israa Abdalgader Madani¹^{, 2}; Omnia Abdullah Eltayeb¹^{, 2}; Yousra A. El-Maradny ¹^{, 3}
¹Microbiology and Immunology, Faculty of Pharmacy, Arab Academy for Science, Technology and Maritime Transport (AASTMT), El Alamein 51718, Egypt.
²School of Pharmacy., Ahfad University for women (AUW), Khartoum , Sudan.
³Pharmaceutical and Fermentation Industries Development Center, City of Scientific Research and Technological Applications (SRTA-City), New Borg EL-Arab, Alexandria, 21934, Egypt.
Abstract
Antimicrobial resistance, or AMR, is one of the major health challenges across the globe because of reduced effectiveness against bacteria, fungi, and viruses. This situation arises when there is significant interference with the effectiveness of antimicrobial agents-antibiotics, antifungals, and antivirals-that are considered essential for treatment. Antimicrobials act selectively against specific targets and metabolic processes of microorganisms. However, pathogens continuously evolve resistance mechanisms and complicate treatment efforts. The modes of action and the mechanisms of resistance are discussed, from the point of view of bacterial, fungal, and viral pathogens, with an overview of emerging therapeutic approaches, such as bacteriophage therapy and plant-derived antimicrobials. Understanding resistance modes is vital to fully harness existing antimicrobials, construct new synthetic agents, and promote responsible antimicrobial stewardship. It will showcase the existing knowledge and identify the gaps in research, therefore providing insight to guide future efforts in addressing AMR.
Keywords
Antimicrobial resistance; bacteriophage; herbal medicine; mechanism of action; one health; sustainable development goals


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