Plasma level of soluble glycoprotein IIb/IIIa in Beta-thalassemia major patients in relation to thrombotic risk score | ||
| Journal of the Medical Research Institute | ||
| Article 1, Volume 45, Issue 4, December 2024, Pages 1-6 PDF (823.4 K) | ||
| Document Type: Review Article | ||
| DOI: 10.21608/jmalexu.2024.335991.1031 | ||
| Authors | ||
| Sally A.M Saleh* 1; Homam Mohamed Sharshera2; Nadia Aly Sadek2; Shereen Mohamed El Maghraby2; Noha Said Kandil3 | ||
| 1249 janaklis | ||
| 2Professor of Hematology, Medical Research Institute, Alexandria University, Egypt | ||
| 3Assistant professor of Hematology, Medical Research Institute, Alexandria University, Egypt | ||
| Abstract | ||
| Background: Multifactorial mechanisms are tangled in the pathogenesis of Thromboembolic events (TEE) in thalassemia major( TM) including the combination of the components of the hemostatic process together with the disease-specific features. GpIIb/IIIa is an integrin complex found on surface of platelets. It is a receptor for fibrinogen and prothrombin. Its activation leads to platelet aggregation. Aim: Estimate the plasma level of s GpIIb/IIIa in β- TM Subjects and methods: The study was conducted on 67 individuals divided into 2groups. The first group included 47 TM patients, while the second group included 20 healthy control subjects. complete physical examination , CBC, serum ferritin, CRP, and s GpIIb/IIIa by ELISA were done. Results The serum level of GpIIb/IIIa was significantly higher in the TM group with a p value Conclusion: TM are characterized by stronger platelet aggregation as reflected by increased GpIIb/IIIa which was associated with high , and intermediate TRT-RSS . | ||
| Keywords | ||
| hypercoagulability; glycoprotein (Gp IIb/IIIa); Thalassemia-related thrombosis risk scoring system (TRT-RSS) | ||
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