Medicinal utility and cardiovascular protection of pomegranate or ginger in the treatment of diabetic/obese rats | ||||
| Journal of Scientific Research in Science | ||||
| Volume 41, Issue 2, 2024, Page 215-237 PDF (574.3 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jsrs.2024.286849.1129 | ||||
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| Authors | ||||
hanaa khairy Abou ELA   1; Rokaya Mohamed Ali Saeed1; Ghada Mazen 2; yassmen said Zaghloul1
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| 1Department of Zoology, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt. | ||||
| 2Biological Applications Department, Nuclear Research Center, Atomic Energy Authority, Egypt | ||||
| Abstract | ||||
| Diabetes and obesity are representing a major public health problem that is on rise worldwide. In this work, a comparison study was occurred between normal control ones, diabetic/obese animals group (without treatment), diabetic/obese rats group treated with 500mg pomegranate/kg b.wt by the aid of oro-gastric tube for one month and diabetic/obese rats group treated with 400mg ginger/kg b.wt by the aid of oro-gastric tube for one month to evaluate the alterations in the carbohydrate profile, lipids picture, heart enzymes activity and cardiac markers associated with the changes in oxidative and antioxidant status in the heart tissues due to experimentally initiation of diabetes/obesity (DM/Ob). Initiation of diabetes/obesity was occurred in rats by the administration of both streptozotocin/nicotinamide to induce diabetes and cholesterol/cholic acid to induce obesity. Comparing to diabetic/obese rats group, significant corrections were occurred in studied parameters after diabetic/obese rats treated by pomegranate or ginger for one month. These findings are consistent with the concept that pomegranate or ginger is hypoglycemic and hypolipidemic agents. The fundamental mechanisms of these properties were explained with obtainable modern researches. | ||||
| Keywords | ||||
| Diabetes mellitus; Obesity; Pomegranate; Ginger; Rats | ||||
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