Efficacy of Intralipid Administration to Improve Pregnancy Rates in Unexplained Intracytoplasmic Sperm Injection (ICSI) Failure | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 4, Volume 98, Issue 1, January 2025, Page 25-29 PDF (448.36 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2025.401093 | ||||
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| Abstract | ||||
| Background: In the field of reproductive medicine, one of the most difficult situations is repeated implantation failure (RIF). It is unknown how intralipid directly affects fertility, however it appears to depend on nature killer (NK) cells cytotoxicity being inhibited, maybe through short fatty acids activating PPARγ receptors. Objectives: The current study aimed to investigate whether intralipid administration could improve the pregnancy outcomes of intracytoplasmic sperm injection (ICSI) cycles in cases with unexplained recurrent implantation failure (RIF). Patients and methods: A total of 112 frozen embryo transfer cycles with history of unexplained RIF were included in a randomized controlled trial and divided into two equal groups: (A) intralipid-treated group (n = 56), received intravenous infusion of intralipid 100 mL of 20% intralipid diluted in 500 mL of normal saline, administrated approximately 7–10 days before frozen embryo transfer and (B) control group (n = 56) underwent frozen embryo transfer without intralipid administration. The primary outcome was clinical pregnancy rate (CPR) Results: Basic and clinicalcharacteristics of the ICSI cycles were matched between groups. In terms of CPR, it was significantly higher in patients received intralipid compared to control group (57.1% versus 37.5%, P value = 0.04). Regarding ongoing pregnancy and miscarriage rates, it was similar in both groups. Univariate analysis revealed that intralipid administration, increased endometrial thickness and lower number of previous failed ICSI were significantly associated with improved clinical pregnancy rates (CPRs). In the multivariate analysis, intralipid administration remained a significant predictor for clinical pregnancy rates. Conclusion: Intralipid infusion is safe and effective therapy in women with RIF that significantly improved the rates of clinical pregnancy. | ||||
| Keywords | ||||
| Intralipid; ICSI; Repeated implantation failure | ||||
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