Platelet Hyperactivity and Thrombosis: Biochemical Mechanisms in Critical Conditions
Mudhhi, E., Al-Enizi, M., Albgami, A., Alarifi, Y., Aljaizani, H., Alwatban, F., Amannaa, S., Alnassar, M., Al Shehaiwin, M., Altayash, F., Alghamdi, F., Aljizani, M., Mhajri, A., Zaebi, H., Almalke, M., Hattan, A., Alrebde, S., Khuwairi, A., Aldousari, Y. (2024). Platelet Hyperactivity and Thrombosis: Biochemical Mechanisms in Critical Conditions. EKB Journal Management System, 67(13), 1787-1793. doi: 10.21608/ejchem.2024.345516.11007
Ebtsam Mudhhi; Maysa Abdulrahman Al-Enizi; Ali Mohammed Albgami; Yousef Abdullah Saad Alarifi; Hasan Ali Hasan Aljaizani; Fahad Musaad Alwatban; Sultan Ibrahim Ahmed Amannaa; Majed Abdulah Alnassar; Mansour Al Shehaiwin; Fawaz Abdulrahman Altayash; Fawaz Saeed Alghamdi; Mohammed Hasan Aljizani; Ali Mousa Mhajri; Hassan Arar Zaebi; Mohammad Ateh Almalke; Ali Yousef Ali Hattan; Sultan Saleh Alrebde; Ali Jabir Khuwairi; Yasser Bakheet Mohammed Aldousari. "Platelet Hyperactivity and Thrombosis: Biochemical Mechanisms in Critical Conditions". EKB Journal Management System, 67, 13, 2024, 1787-1793. doi: 10.21608/ejchem.2024.345516.11007
Mudhhi, E., Al-Enizi, M., Albgami, A., Alarifi, Y., Aljaizani, H., Alwatban, F., Amannaa, S., Alnassar, M., Al Shehaiwin, M., Altayash, F., Alghamdi, F., Aljizani, M., Mhajri, A., Zaebi, H., Almalke, M., Hattan, A., Alrebde, S., Khuwairi, A., Aldousari, Y. (2024). 'Platelet Hyperactivity and Thrombosis: Biochemical Mechanisms in Critical Conditions', EKB Journal Management System, 67(13), pp. 1787-1793. doi: 10.21608/ejchem.2024.345516.11007
Mudhhi, E., Al-Enizi, M., Albgami, A., Alarifi, Y., Aljaizani, H., Alwatban, F., Amannaa, S., Alnassar, M., Al Shehaiwin, M., Altayash, F., Alghamdi, F., Aljizani, M., Mhajri, A., Zaebi, H., Almalke, M., Hattan, A., Alrebde, S., Khuwairi, A., Aldousari, Y. Platelet Hyperactivity and Thrombosis: Biochemical Mechanisms in Critical Conditions. EKB Journal Management System, 2024; 67(13): 1787-1793. doi: 10.21608/ejchem.2024.345516.11007

Platelet Hyperactivity and Thrombosis: Biochemical Mechanisms in Critical Conditions

Egyptian Journal of Chemistry
Volume 67, Issue 13, December 2024, Page 1787-1793  XML PDF (438.35 K)
Document Type: Review Articles
DOI: 10.21608/ejchem.2024.345516.11007
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Authors
Ebtsam Mudhhi; Maysa Abdulrahman Al-Enizi; Ali Mohammed Albgami; Yousef Abdullah Saad Alarifi; Hasan Ali Hasan Aljaizani; Fahad Musaad Alwatban; Sultan Ibrahim Ahmed Amannaa; Majed Abdulah Alnassar; Mansour Al Shehaiwin; Fawaz Abdulrahman Altayash; Fawaz Saeed Alghamdi; Mohammed Hasan Aljizani; Ali Mousa Mhajri; Hassan Arar Zaebi; Mohammad Ateh Almalke; Ali Yousef Ali Hattan; Sultan Saleh Alrebde; Ali Jabir Khuwairi; Yasser Bakheet Mohammed Aldousari
King Saud Medical City, Riyadh, Saudi Arabia
Abstract
Background: Platelet hyperactivity has a central role in the process of thrombosis during important stages like injury, sepsis, and cardiovascular events. Platelets are required for hemostatic plug formation, but the activation of platelets can also result in formation of pathological thrombi and life threatening events.
Aim: The goal of the present research is to examine the metabolic background of platelet hyperactivity and its implication in thrombosis in severe medical conditions.
Methods: A literature review was performed and the findings based on the biochemical processes accounting for platelet activation and aggregation during trauma, sepsis and cardiovascular diseases have been reported.
Results: The review identified that inflammation, oxidative stress and endothelial dysfunction are main factors that influence the platelet activation and thereby enhancing the thrombus formation and corresponding risks of stroke, myocardial infarction and pulmonary embolism.
Conclusion: Hyperactivity of platelets is essential during thrombosis in critical conditions. Knowledge of such biochemical pathways displays practical approaches on how the thrombotic risks that are so characteristic of individual critically endangered can be controlled.
Keywords
Hyperactivity; Thrombosis; Critical illness; activated platelets; inflammation; platelet; oxidant stress
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