“Tissue and/or Serum Expression levels of miRNA-31 and miRNA-141 as potential diagnostic markers for Colon Cancer in Egyptian Patients” | ||
| Journal of the Medical Research Institute | ||
| Article 5, Volume 45, Issue 4, December 2024, Pages 43-52 PDF (450.35 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jmalexu.2024.340947.1038 | ||
| Authors | ||
| Noha Said Kandil* 1; mohamed abdelrahman2; mohamed kamel3; mohamed shamsya3; Mona Abdel Ghany Haiba3; Maher A Kamel4; thanaa moghazy3 | ||
| 1Chemical pathology reaction | ||
| 2military hospital | ||
| 3mri | ||
| 4Department of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt | ||
| Abstract | ||
| Cancer colon is the most common cancer of the digestive tract representing the third most common cancer. MiRNAs regulate 30% of human genes. They can act as oncogenes and tumor suppressors. MiRNA-31 expression level is altered in many cancers; it is increased in squamous cell carcinoma, and hepatocellular carcinoma, but significantly decreased in gastric, breast, and prostate cancer. MiRNA-141 is an important member of the miR-200 family regulates different cellular processes, such as proliferation and angiogenesis. The study aimed to determine the tissue and serum expression of miR-31 and miR-141 in Egyptian patients with cancer colon. Fifty subjects were enrolled in this study. They were divided into 2 groups; Group I: 25 newly diagnosed stage II and III primary cancer colon patients, and Group II: 25 healthy controls. Increased expression of miRNA-31 in cancerous tissue more than adjacent noncancerous tissue was observed. Regarding miRNA-141; there was a significant increase in serum miRNA-141 in cancer colon group than the control group. A ROC curve showed that AUC for serum miRNA-141 was 0.869. This suggests the possible use of serum miRNA-141 in diagnosis of CC. | ||
| Keywords | ||
| MiRNA-31; MiRNA-141; cancer colon | ||
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