HOX genes: molecular genetics and effect of mutation
Rezka, H., Sakr, H., Ismaile, A., Almowallad, A., Almaqboule, T., Alqawlaq, A., Albassame, J., Bukharie, A., Almoshawar, H. (2025). HOX genes: molecular genetics and effect of mutation. EKB Journal Management System, 24(1), 1-9. doi: 10.21608/epj.2025.402029
Hassan M. Rezka; Hader I. Sakr; Abeer O. Ismaile; Alaa A. Almowallad; Taif M. Almaqboule; Abdulelah K. Alqawlaq; Joud A. Albassame; Abdulaziz A. Bukharie; Hadi H. Almoshawar. "HOX genes: molecular genetics and effect of mutation". EKB Journal Management System, 24, 1, 2025, 1-9. doi: 10.21608/epj.2025.402029
Rezka, H., Sakr, H., Ismaile, A., Almowallad, A., Almaqboule, T., Alqawlaq, A., Albassame, J., Bukharie, A., Almoshawar, H. (2025). 'HOX genes: molecular genetics and effect of mutation', EKB Journal Management System, 24(1), pp. 1-9. doi: 10.21608/epj.2025.402029
Rezka, H., Sakr, H., Ismaile, A., Almowallad, A., Almaqboule, T., Alqawlaq, A., Albassame, J., Bukharie, A., Almoshawar, H. HOX genes: molecular genetics and effect of mutation. EKB Journal Management System, 2025; 24(1): 1-9. doi: 10.21608/epj.2025.402029

HOX genes: molecular genetics and effect of mutation

Egyptian Pharmaceutical Journal
Article 1, Volume 24, Issue 1, January 2025, Page 1-9  XML PDF (163.47 K)
DOI: 10.21608/epj.2025.402029
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Authors
Hassan M. Rezka1; Hader I. Sakr2; Abeer O. Ismaile3; Alaa A. Almowallad3; Taif M. Almaqboule3; Abdulelah K. Alqawlaq3; Joud A. Albassame3; Abdulaziz A. Bukharie3; Hadi H. Almoshawar3
1Department of Anatomy & Embryology, Mansoura University, Mansoura,
2Department of Medical Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo, Egypt
3General surgery Department, General Medicine Practice Program, Batterjee Medical College, Jeddah, Saudi Arabia
Abstract
In vertebrates, the axial skeleton, limbs, stomach, urogenital tract, and external
genitalia all develop partly controlled by the homeobox-containing HOX gene
families, which are deeply conserved throughout animal evolution. Much
knowledge has been learned about the functions of HOX genes in many
physiological and pathologic processes since their original discovery. There are
39 HOX genes in mammals, separated into the HOX A, B, C, and D clusters. Thirtynine
homeobox genes in mammals are clustered into four clusters: HOX A–D, with
a correlation between mutations of HOXB13, most often G84E, with breast,
colorectal, and early-onset prostate cancer in humans. Here, we discuss the
current knowledge of homeobox signaling in genitourinary development and
cancer and the role of homeobox protein cofactors in both development and cancer
Keywords
Bosley–Salih–Alorainy syndrome; human HOX disorders; prostate cancer; synpolydactyly type II
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