Genetic Factors in Preeclamptic Egyptian Women: Relation with Arginine Vasopressin; A Case-Control Study
Younis, N., Rashed, L., El-mandoury, A., Ellakwa, D. (2025). Genetic Factors in Preeclamptic Egyptian Women: Relation with Arginine Vasopressin; A Case-Control Study. EKB Journal Management System, 5(1), 202-215. doi: 10.21608/aijpms.2024.185070.1186
Naglaa F Younis; Laila A Rashed; Ahmed A El-mandoury; Doha E Ellakwa. "Genetic Factors in Preeclamptic Egyptian Women: Relation with Arginine Vasopressin; A Case-Control Study". EKB Journal Management System, 5, 1, 2025, 202-215. doi: 10.21608/aijpms.2024.185070.1186
Younis, N., Rashed, L., El-mandoury, A., Ellakwa, D. (2025). 'Genetic Factors in Preeclamptic Egyptian Women: Relation with Arginine Vasopressin; A Case-Control Study', EKB Journal Management System, 5(1), pp. 202-215. doi: 10.21608/aijpms.2024.185070.1186
Younis, N., Rashed, L., El-mandoury, A., Ellakwa, D. Genetic Factors in Preeclamptic Egyptian Women: Relation with Arginine Vasopressin; A Case-Control Study. EKB Journal Management System, 2025; 5(1): 202-215. doi: 10.21608/aijpms.2024.185070.1186

Genetic Factors in Preeclamptic Egyptian Women: Relation with Arginine Vasopressin; A Case-Control Study

Azhar International Journal of Pharmaceutical and Medical Sciences
Article 17, Volume 5, Issue 1, January 2025, Page 202-215  XML PDF (546.88 K)
Document Type: Case studies
DOI: 10.21608/aijpms.2024.185070.1186
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Authors
Naglaa F Younis email orcid 1; Laila A Rashed2; Ahmed A El-mandoury3; Doha E Ellakwa4
1Department of Clinical Pharmacy, Manshyet El- Bakry Hospital, Cairo, Egypt.
2Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Egypt.
3Department of Obstetrics and Gynecology, Faculty of Medicine, 6 Oct University, Egypt.
4Department of Biochemistry and Molecular Biology, Faculty of Pharmacy (girls), Al-Azhar University, Egypt.
Abstract
Abastract ;
Preeclampsia (PE) is one of the leading causes of prenatal and maternal deaths; therefore developing new biomarkers at the earliest stages of illness is essential to accelerating effectiveness. Using serum microRNA 149 and copeptin to diagnose preeclampsia will be investigated in this study. We conducted a matched case–control study in Egyptian women. Seventy women between 28 and 40 weeks of pregnancy participated in the study and divided into two groups: 20 pregnant women without PE and 50 with PE. Blood biochemical parameters were assessed for all subjects in addition to genetic analysis for microRNA 149 was detected by RT-PCR. Serum copeptin was detected by ELISA. The present study demonstrated that ; preeclamptic patients had considerably lower serum levels of miR-149 than control cases at (p≤0.01). Meanwhile, preeclamptic patients had considerably higher serum levels of copeptin than controls at (p≤0.01). Serum copeptin levels may provide early indicators of preeclampsia.
Keywords
Preeclampsia; MicroRNA149; Copeptin; proteinuria; prothrombin time and concentration; RT-PCR
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