Low At-admission Serum Omentin-1 Levels with High Delta-SOFA Are Early Predictors of the Outcome of Sepsis Patients Admitted to Surgical ICU
Mostafa, I., Elnady, M., Alnoury, H., Elnoury, A. (2024). Low At-admission Serum Omentin-1 Levels with High Delta-SOFA Are Early Predictors of the Outcome of Sepsis Patients Admitted to Surgical ICU. EKB Journal Management System, 7(2), 967-981. doi: 10.21608/svuijm.2024.332012.2002
Ibrahim EM Mostafa; Mahmoud Mohamed Elnady; Hamasat A Alnoury; Ahmed Said Elnoury. "Low At-admission Serum Omentin-1 Levels with High Delta-SOFA Are Early Predictors of the Outcome of Sepsis Patients Admitted to Surgical ICU". EKB Journal Management System, 7, 2, 2024, 967-981. doi: 10.21608/svuijm.2024.332012.2002
Mostafa, I., Elnady, M., Alnoury, H., Elnoury, A. (2024). 'Low At-admission Serum Omentin-1 Levels with High Delta-SOFA Are Early Predictors of the Outcome of Sepsis Patients Admitted to Surgical ICU', EKB Journal Management System, 7(2), pp. 967-981. doi: 10.21608/svuijm.2024.332012.2002
Mostafa, I., Elnady, M., Alnoury, H., Elnoury, A. Low At-admission Serum Omentin-1 Levels with High Delta-SOFA Are Early Predictors of the Outcome of Sepsis Patients Admitted to Surgical ICU. EKB Journal Management System, 2024; 7(2): 967-981. doi: 10.21608/svuijm.2024.332012.2002

Low At-admission Serum Omentin-1 Levels with High Delta-SOFA Are Early Predictors of the Outcome of Sepsis Patients Admitted to Surgical ICU

SVU-International Journal of Medical Sciences
Article 84, Volume 7, Issue 2, July 2024, Page 967-981  XML PDF (514.09 K)
Document Type: Original research articles
DOI: 10.21608/svuijm.2024.332012.2002
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Authors
Ibrahim EM Mostafa1; Mahmoud Mohamed Elnady1; Hamasat A Alnoury2; Ahmed Said Elnoury email 1
1Department of Anesthesia, ICU & Pain, Faculty of Medicine, Benha University, Benha, Egypt.
2Department of Chemical & Clinical Pathology, Faculty of Medicine, Benha University, Benha, Egypt
Abstract
Background: Despite the progress in the management of sepsis, the shortcomings of routine investigations necessitated the search for new biomarkers to be used as early predictors for sepsis outcomes.
Objectives: To define the relations of progress to septic shock (SS) and mortality rate (MR) among sepsis patients with serum omentin-1 levels estimated at admission to the surgical ICU.
Patients and methods: 160 sepsis patients were evaluated using the quick sepsis-related Organ Failure Assessment (q-SOFA) score and SOFA score at admission (T0-time) and 24 h thereafter (T24) to calculate delta-SOFA (∆SOFA). The frequency of SS and the 28-d MR were determined. The study outcome is defining the relation of lab parameters estimated at T0-time and ∆SOFA for the incidence of SS and MR.
Results: SS was diagnosed in 53 patients, and the total MR was 23.125%. The incidence of the development of SS and ICU mortality was positively correlated with ∆SOFA but was negatively correlated with at-admission serum omentin-1 levels. Serum omentin-1 levels showed a negative significant correlation with ∆SOFA (P=0.008) and serum levels of C-reactive protein (P=0.030), interleukin-6 (P=0.004), and tumor necrosis factor-α (P=0.014).
Conclusion: The calculated ∆SOFA at 24 h after ICU admission is preferable to SOFA scoring to determine the change in evaluated parameters through 24 h. Combined high ∆SOFA and at-admission low serum omentin-1 were significantly correlated with the incidence of SS and mortality at the surgical ICU and might be used as early identifiers for patients vulnerable to bad outcomes.
Keywords
Sepsis; Surgical ICU, mortality; Omentin-1; SOFA; q-SOFA; Inflammatory cytokines
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