ACUTE SAFETY STUDY OF SALVIA OFFICINALIS TERPENOIDS RICH FRACTION IN WISTAR RATS | ||||
| Assiut Veterinary Medical Journal | ||||
| Volume 71, Issue 184, January 2025, Page 386-400 PDF (1.56 MB) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.2025.333302.1459 | ||||
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| Authors | ||||
MARIAN G. SAWERUS   1; WALAA M.S. AHMED2; OLFAT SHEHATA1; DALIA EL AMIR3; FATMA KHALIL4; EMAD A. MAHDI5; HAMDY H. KAMEL2
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| 1Department of Clinical Pathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt | ||||
| 2Department of Clinical Pathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt. | ||||
| 3Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt | ||||
| 4Animal and Poultry Management and Wealth Development, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt. | ||||
| 5Department of Pathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt | ||||
| Abstract | ||||
| ABSTRACT Salvia plants become more popular due to their health-promoting and antioxidant potential. The present study aimed to investigate the safety limit of Salvia officinalis terpenoids-rich fraction in Wistar rats. Thirty adult female rats were divided equally into three groups. The first one was control. The second and third groups received Salvia fraction as a single oral dose of 2 and 3 g/kg b.w., respectively. During the experimental period, any abnormal clinical signs, morbidity and mortality rates, as well as weekly body weight gain were recorded. At the end of the experiment, behavior tests were performed and blood specimens were collected for hematological and biochemical examinations. The liver and kidney were collected for histopathology. There were no abnormal variations in clinical signs or weight gain at both doses. Salvia fraction at both doses had a distinct anxiolytic effect; however, it improved working memory only at the 2 g/kg b.w. group. There was an increment in locomotor activity in rats receiving 3 g/kg b.w. For hematology and clinical biochemistry, there was mild leucopenia accompanied by absolute lymphopenia and a decrease in ALT and AST activities in rats receiving 3 g/kg b.w. of Salvia fraction, besides no significant change in urea and creatinine in both treated groups. In conclusion, the Salvia officinalis terpenoids-rich fraction appears to have no adverse toxic effects, except for minimal alterations in leucogram, liver enzymes, and hepatic and renal tissues induced in rats treated with 3 g/kg b.w, of the Salvia fraction. Key words: Salvia officinalis, terpenoids, safety, rats. | ||||
| Keywords | ||||
| Salvia officinalis; terpenoids; safety; rats | ||||
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