Metabolic volumetric parameters versus Deauville scoring for therapy response in multiple myeloma patients. | ||
| Egyptian Journal Nuclear Medicine | ||
| Volume 29, Issue 2, December 2024, Pages 40-47 PDF (203.32 K) | ||
| Document Type: Original Paper, PET/CT | ||
| DOI: 10.21608/egyjnm.2024.325598.1106 | ||
| Authors | ||
| Maha Mehesen* 1; Hosna Moustafa2; Aya Ashraf3; huda fathy4; Ehab Mosaad Abdelghany5; Salwa Abd El-Gaid6 | ||
| 1nuclear medicine, national cancer institute, Cairo, Egypt | ||
| 2Oncology and Nuclear Medicine Department, Kasr Al-Aini Hospital, Cairo University, Egypt. | ||
| 3Nuclear medicine unit, National Cancer Institute, Cairo University. | ||
| 4nuclear medicine department, National Cancer Institute, Cairo University, Cairo, Egypt. | ||
| 5Medical Oncology Department, National Cancer Institute, Cairo University. | ||
| 6Nuclear Medicine Unit, National Cancer Institute (NCI) Cairo University, Cairo, Egypt. | ||
| Abstract | ||
| Background: 18F-FDG PET/CT is an efficient modality to monitor minimal residual disease (MRD), detect extra-medullary disease, assess disease burden, and therapy response in multiple myeloma patients. Purpose: The aim of this study is to assess therapy response in MM patients using both Deauville scoring (DS) and metabolic volumetric parameters and detect their predictive value. Patients and methods: A total of 50 adult patients newly diagnosed with multiple myeloma (MM) were prospectively evaluated. Using DS and metabolic parameters for analysis of initial and interim FDG-PET/CT scans , and then their prognostic value was detected. Results: No statistical significance was detected for DS either in initial or interim PET/CT studies. Regarding the metabolic parameters, initial metabolic tumor volume (MTV) and TLG between responder and non-responder categories showed notable significance with a p value of 0.004. Moreover, interim MTV, total lesion glycolysis (TLG) and SUVpeak determined p values of 0.021, 0.009, and 0.007, respectively. Conclusion: Metabolic volumetric parameters were promising tools to predict outcome in MM patients. The cutoff of initial MTV greater than 70 showed sensitivity of 78 % and specificity of 71.4%. The sensitivity of 56% and specificity of 93% for the cutoff of initial TLG more than 350. Interim SUVpeak level with a cutoff point of more than 3, showing sensitivity of 86% and specificity of 73%. | ||
| Keywords | ||
| Metabolic volumetric parameters; Deauville scoring; therapy response; multiple myeloma patients | ||
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