Packed RBCs versus sodium bicarbonate in the treatment of aluminum phosphide-induced cardiotoxicity and metabolic acidosis in rats
Mahmoud, ., Tighian, A., Refaie, M., Asem, M., Abdel Zaher, A., Shehata, S., Mahmoud, E. (2025). Packed RBCs versus sodium bicarbonate in the treatment of aluminum phosphide-induced cardiotoxicity and metabolic acidosis in rats. EKB Journal Management System, 44(1), 48-56. doi: 10.21608/ajfm.2025.337915.1151
ُEman Shaaban Mahmoud; Asmaa Tighian; Marwa Refaie; Mostafa Asem; Azza Abdel Zaher; Sayed Shehata; Eman Mahmoud. "Packed RBCs versus sodium bicarbonate in the treatment of aluminum phosphide-induced cardiotoxicity and metabolic acidosis in rats". EKB Journal Management System, 44, 1, 2025, 48-56. doi: 10.21608/ajfm.2025.337915.1151
Mahmoud, ., Tighian, A., Refaie, M., Asem, M., Abdel Zaher, A., Shehata, S., Mahmoud, E. (2025). 'Packed RBCs versus sodium bicarbonate in the treatment of aluminum phosphide-induced cardiotoxicity and metabolic acidosis in rats', EKB Journal Management System, 44(1), pp. 48-56. doi: 10.21608/ajfm.2025.337915.1151
Mahmoud, ., Tighian, A., Refaie, M., Asem, M., Abdel Zaher, A., Shehata, S., Mahmoud, E. Packed RBCs versus sodium bicarbonate in the treatment of aluminum phosphide-induced cardiotoxicity and metabolic acidosis in rats. EKB Journal Management System, 2025; 44(1): 48-56. doi: 10.21608/ajfm.2025.337915.1151

Packed RBCs versus sodium bicarbonate in the treatment of aluminum phosphide-induced cardiotoxicity and metabolic acidosis in rats

Ain Shams Journal of Forensic Medicine and Clinical Toxicology
Volume 44, Issue 1, January 2025, Page 48-56  XML PDF (1.34 MB)
Document Type: Original Article
DOI: 10.21608/ajfm.2025.337915.1151
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Authors
ُEman Shaaban Mahmoud email 1; Asmaa Tighian2; Marwa Refaie3; Mostafa Asem2; Azza Abdel Zaher4; Sayed Shehata5; Eman Mahmoud2
1Department of forensic medicine and clinical toxicology, Faculty of medicine, Minia University
2Departement of forensic medicine and clinical toxicology, faculty of medicine, Minia university
3Departement of pharmacology, faculty of medicine, Minia university
4Departement of pathology, faculty of medicine, Minia university
5Departement of cardiology, faculty of medicine, Minia university
Abstract
Background: Human toxicity with aluminum phosphide (ALP) is usually associated with intense metabolic acidosis and cardiac ischemia which are the main cause of death. Aim of the study is to assess and compare the effectiveness of fresh packed RBCs and sodium bicarbonate in treatment of ALP toxicity. Methodology: This experimental study was conducted during the period from 1st to 8th March 2022 on 50 rats divided randomly into five groups: group I received Almond oil (control group), while the others were exposed to aluminum phosphide (12 mg/kg). Group III was given NaHCO3 (3 mmol/kg), group IV received packed RBCs (1.5 ml) and group V was treated by both packed RBCs and NaHCO3. Electrocardiogram, arterial blood gases, serum levels of cardiac troponin I, and histopathological examination of the heart were done for all rats. Results: ALP resulted in significant bradycardia (p=0.002), prolongation of QT interval (p<0.001), widening of QRS complex (p<0.001), elevation of ST segment (p<0.001), resistant metabolic acidosis (p<0.001) and increased troponin level (p<0.001). Histopathological examination revealed severe cardiac ischemic changes due to ALP exposure.  Packed RBCs + NaHCO3 significantly improved bradycardia (p=0.025). Packed RBCs alone and packed RBCs plus NaHCO3 significantly improved chemical and histopathological changes. However, the combination therapy demonstrated greater benefits compared to packed RBCs alone. Conclusion: These findings suggest using packed RBCs alone or with NaHCO3 to boost survival rates in ALP poisoning
Keywords
ALP; packed RBCs; ECG; NaHCO3; ABG
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