Hepatocellular Carcinoma after Treatment of Cirrhotic Hepatitis C Virus Patients with Direct Acting Antiviral Treatment | ||
| Azhar International Journal of Pharmaceutical and Medical Sciences | ||
| Article 2, Volume 5, Issue 1, January 2025, Pages 17-26 PDF (310.47 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/aijpms.2024.181518.1183 | ||
| Authors | ||
| Nourhan Fekry* 1; EL- Sayed Abd Elmaqsoud2; Zeinab Al Kasaby3; Karima Abu-ElFotuh4 | ||
| 1Sinbillawine General Hospital Daqahlia, Egypt | ||
| 2Department of Internal Medicine (Hepato gastroentrology) Faculty of Medicine, Mansoura University, Egypt | ||
| 3Department of Clinical Pharmacy, Faculty of Pharmacy (Girls) Al-Azhar University, Cairo, Egypt | ||
| 4Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo 11651, Egypt | ||
| Abstract | ||
| Earlier treatment plans based on the use of interferon (IFN) were characterised by a sustained virological response (SVR) of 40–50%., but Since direct acting anti viral therapy (DAAs) introduced to treat chronic hepatitis (C) patients , result in interesting high rate of sustained virologic response by 95% with a good safety profile with reduction in death rate as well as hepatocellular carcinoma (HCC) ,despite this high rate of SVR the risk of (HCC) doesn't eliminated , data puplished in 2016 were a source of worry regarding the (HCC) appear post treatment either de novo or recurrence , in addition tumour characteristic after DAAs more aggressive , Discovered that following DAAs tumours displayed aggressive behaviour, had a larger number of nodules, and had extrahepatic metastases, demonstrating that cancer growth is faster than expected in these patients, this is because The use of powerful IFN-free DAAs treatments may result in rapid viral suppression and reduce inflammatory cytokine responses . | ||
| Keywords | ||
| Hepatitis C virus; Sustained virologic response; Direct-acting antiviral therapy; Hepatocellular carcinoma; Liver cirrhosis | ||
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