Letrozole a Novel Treatment for Undisturbed Ectopic Pregnancy | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 89, Volume 7, Issue 2, July 2024, Page 1031-1037 PDF (332.47 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/svuijm.2023.189322.1504 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Abd EL-Naser Abd EL-Gaber Ali; Mostafa Khodry; Moaz Hamada Mohamed 
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| Department of Obstetrics and Gynecology, Faculty of Medicine, South Valley University, Qena, Egypt | ||||
| Abstract | ||||
| Background: The fallopian tube is where ectopic pregnancies most frequently occur. Methotrexate or minimally invasive surgery can successfully treat the majority of early-detected tubal ectopic pregnancy cases. Objectives: This study's objective is to evaluate letrozole as a potential new treatment for ectopic pregnancy. Patients and methods: The Obstetrics and Gynecology Department of Qena University Hospital carried out this cohort study. The study included 40 cases with non-disturbed ectopic tubal pregnancy. They were divided into two groups; group took Letrozole (20 cases), and group took methotrexate (20 cases). The duration of the study ranged from 6- 12months. Results: as regard success of treatment was achieved in 85% of letrozole cases versus 80% in methotrexate cases with insignificant differences. Maternal morbidity was insignificant between two groups as in letrozole group 2 cases transferred to surgery and 1 case shifted to methotrexate, in methotrexate 4 cases transferred to surgery. Conclusion: Success rates for both treatment arms of letrozole and methotrexate were 86%. Even though the difference was statistically significant, women treated with letrozole rather than methotrexate tended to experience a faster decline in B-Human Chorionic Gonadotropin levels. | ||||
| Keywords | ||||
| Letrozole; Undisturbed ectopic pregnancy; beta HCG; Medical treatment; Methotrexate | ||||
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