Characterization of Degradation Products Resulted from Acidic Hydrolysis of Lisinopril Under Drastic Conditions | ||
| Journal of Advanced Pharmacy Research | ||
| Article 4, Volume 1, Issue 4, October 2017, Pages 201-208 PDF (913.8 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/aprh.2017.4041 | ||
| Authors | ||
| Eman El-Leithy1, 2; Gena El-Fiky1, 3; Mohamed Nabil4 | ||
| 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6thof October, Giza, Egypt. | ||
| 22Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, AinHelwan, Cairo, Egypt | ||
| 3Pharmaceutical Technology Devision, National Research Center, El-Dokki, Giza, Egypt. | ||
| 410th of Ramadan for Pharmaceutical and DiagnosticReagents, 6thof October, Giza, Egypt. | ||
| Abstract | ||
| Four degradation products resulted from acidic hydrolysis of lisinopril under drastic conditions. The degradation products were detected by means of ultra-performance liquid chromatography coupled with mass/mass spectroscopy (LC-MS/MS) with simple and sensitive method suitable for LC-MS/MS analysis. The fragmentation behaviors of lisinopril and degradation products were investigated. Two degradation products were described in E.Ph.(8th) as impurities. Both of 6-amino-2-((1-carboxy-3-phenylpropyl)amino) hexanoic acid (m/z 309+)and 1-(2,6-diaminohexanoyl)pyrrolidine-2-carboxylic acid (m/z 244+) were formed and identified. | ||
| Keywords | ||
| Lisinopril analysis; Degradation products; LC-MS/MS; Chemical structure elucidation | ||
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