Evaluation of the effect of systemic antifungal on the Radiologic and Endoscopic outcome after Endoscopic Sinus Surgery in patients with Allergic Fungal Rhinosinusitis | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 12 January 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2025.348588.1863 | ||
| Authors | ||
| khalaf Hamead1; Abd El Rehim singer2; Mostafa Ismail Ahmed3; Abdelhakim Atef Abdelhakim* 4; Khaled Mohammed Abdelzaher5 | ||
| 1otorhinolaryngology department ,faculty of medicine, Minia university | ||
| 2otolaryngeology department, faculty of medicine,minia university | ||
| 3ENT department,Faculty of Medicine, Minia University | ||
| 4Department of Otorhinolaryngology, faculty of medicine, Minia University | ||
| 5E.N.T department Faculty of Medicine -El- Minia University Egypt | ||
| Abstract | ||
| Abstract Background: Allergic Fungal Rhinosinusitis (AFRS) is a serious problem that affects quality of life. With Limited effective postoperative therapies existing we discuss the role of systemic Itraconazole as an adjunctive therapeutic agent postoperatively. Aim of the study: Evaluation of the effect of systemic Itraconazole after functional endoscopic sinus surgery (FESS) in Allergic Fungal Rhinosinusitis patients. Patients and methods: In the study, we recruited 20 patients diagnosed with Allergic Fungal Rhinosinusitis (AFRS) From the E.N.T outpatient clinic of Minia University Hospital. Patients received oral systemic Itraconazole for 6 weeks after endoscopic sinus surgery. Results: There is a marked statistically significant difference found between the pre-operative and the post-operative Endoscopic staging score of Lund Kennedy (p=0.001). The median staging before the treatment with itraconazole was 8 which changed to 3 after the treatment & the pre-operative and post-operative CT Lund-Mackay scores demonstrate a difference that is statistically significant (p<0.01). The median score was 13 preoperatively which changed to 6 postoperatively. Conclusions: In conclusion, our findings indicated that using Systemic Itraconazole significantly reduced the radiologic and endoscopic staging in AFRS patients. Notably, A highly statistically significant improvement in CT and Endoscopic findings after treatment compared to before, underscoring the potential benefit of Itraconazole in addressing AFRS after endoscopic sinus surgery. Keywords: Itraconazole,FESS, Endoscopic, Radiologic, Allergic fungal sinusitis. | ||
| Keywords | ||
| Itraconazole; FESS; Endoscopic; Radiologic; Allergic fungal sinusitis | ||
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