The Effectiveness of Urinary TIMP-2 and L-FABP in Predicting Acute Kidney Injury in Critically Ill Neonates | ||||
| Benha Medical Journal | ||||
| Article 5, Volume 42, Issue 7, July 2025, Page 730-739 PDF (786.19 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2024.336599.2255 | ||||
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| Authors | ||||
Wesam E. Afifi1; Mohamed M. El-Bakry2; Randa A.H. Elaskary  3; Maha M. Osman4
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| 1Department of Pediatric , Faculty of Medicine, Benha University, Egypt. | ||||
| 2Department Pediatric Department, Faculty of Medicine–Benha University, Benha, Egypt. | ||||
| 3MB.B.CH of Pediatric Department, Damanhour Medical National Institue, Damanhour–Elbehira, Egypt. | ||||
| 4Department of Clinical & Chemical Pathology , Faculty of Medicine, Helwan University, Cairo, Egypt. | ||||
| Abstract | ||||
| Background: Acute kidney injury which is known as (AKI) is correlated with high death and morbidity in critically diseased neonates. Aim: To evaluate the effectiveness of L-FABP and urinary TIMP-2 in predicting acute kidney injury. Methods: Prospective cohort research was conducted on eighty-eight critically diseased newborns ranging in age from one day to twenty-eight days. These neonates have been admitted to the Neonatal Intensive Care Unit (NICU) of the Pediatric Department at Benha University Hospital. Results: A significant variance has been detected among both groups as regards SNAPPE score, TIMP-2 and L-FABP. There was a significant decrease in hematocrit, hemoglobin and platelets levels at the follow-up laboratory data, while a significant rise has been detected in CRP, creatinine, urea and serum K. a significant positive association has been detected has been detected between urinary TIMP-2 and SNAPPE score, SBP, serum K and L-FABP. Also, there was a significant positive association among urinary L-FABP and SBP, SNAPPE score and Serum K. Urinary TIMP-2 had the greatest sensitivity and specificity at 4.57 ng/ml. Also, L-FABP had the greatest sensitivity and specificity at 6.25 ng/ml. Analysis showed that urinary TIMP-2 + L-FABP had 96% sensitivity and 98.9% specificity. SNAPPE score, APGAR score, urinary TIMP-2 and urinary L-FABP can be used as independent factors for predicting AKI. Conclusion: Urinary TIMP-2 and L-FABP levels were higher among the AKI group, with levels in the KDIGO stage 2 group being even greater, which were considered as early detectors of AKI. | ||||
| Keywords | ||||
| Neonates; u TIMP-2; u L-FABP; AKI | ||||
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