Assessment of the Relationship between Vitamin D Status and Graft Function in Living-Related Kidney Transplant Recipients
Gabr, A., Khalil, M., Mogahed, M., Eltaweel, B., Marei, Y., El Hammady, A. (2025). Assessment of the Relationship between Vitamin D Status and Graft Function in Living-Related Kidney Transplant Recipients. EKB Journal Management System, 8(1), 1-11. doi: 10.21608/svuijm.2025.342302.2047
Ahmad Al Sayed M. Gabr; Medhat A. Khalil; Mysara M. Mogahed; Basma A. Eltaweel; Yomna Mohammed Marei; Amr M. El Hammady. "Assessment of the Relationship between Vitamin D Status and Graft Function in Living-Related Kidney Transplant Recipients". EKB Journal Management System, 8, 1, 2025, 1-11. doi: 10.21608/svuijm.2025.342302.2047
Gabr, A., Khalil, M., Mogahed, M., Eltaweel, B., Marei, Y., El Hammady, A. (2025). 'Assessment of the Relationship between Vitamin D Status and Graft Function in Living-Related Kidney Transplant Recipients', EKB Journal Management System, 8(1), pp. 1-11. doi: 10.21608/svuijm.2025.342302.2047
Gabr, A., Khalil, M., Mogahed, M., Eltaweel, B., Marei, Y., El Hammady, A. Assessment of the Relationship between Vitamin D Status and Graft Function in Living-Related Kidney Transplant Recipients. EKB Journal Management System, 2025; 8(1): 1-11. doi: 10.21608/svuijm.2025.342302.2047

Assessment of the Relationship between Vitamin D Status and Graft Function in Living-Related Kidney Transplant Recipients

SVU-International Journal of Medical Sciences
Article 2, Volume 8, Issue 1, January 2025, Page 1-11  XML PDF (318.97 K)
Document Type: Original research articles
DOI: 10.21608/svuijm.2025.342302.2047
View on SCiNiTO View on SCiNiTO
Authors
Ahmad Al Sayed M. Gabr1; Medhat A. Khalil2; Mysara M. Mogahed2; Basma A. Eltaweel1; Yomna Mohammed Marei2; Amr M. El Hammady email orcid 2
1Department of Nephrology, National Institute of Urology and Nephrology, Cairo, Egypt.
2Department of Internal Medicine, Faculty of Medicine, Benha University, Benha, Egypt.
Abstract
Background: Kidney transplantation enhances survival rates and quality of life for patients with end-stage renal disease (ESRD). However, the long-term function of graft can be compromised. A common issue among transplant recipients is vitamin D deficiency, which arises due to the use of immunosuppressants and sun protection measures, potentially contributing to the deterioration of the allograft.
Objectives: To determine the incidence of vitamin D deficiency in kidney transplant recipients and its relationship with graft function.
Patients and methods: A prospective observational study, including 50 CKD patients undergoing kidney transplant collected from Internal Medicine department, Benha university and National Institute of Urology and Nephrology. Patients were grouped based on serum 25(OH) vitamin D levels into sufficient (≥30 ng/ml) and insufficient (<30 ng/ml) groups. Comprehensive evaluations were performed, including clinical exams and laboratory tests (CBC, CRP, blood urea, creatinine, eGFR, tacrolimus levels, and serum 25(OH)D levels) before and at 6 weeks, 3 months, and 6 months post-transplant.
Results: The study participants recipients with 36.13 ± 12.33 years in the sufficient vitamin D group and 26.76 ± 9.16 years in the insufficient group. There was no statistically significant difference between the two groups regarding serum urea, creatinine and eGFR over time. Serum urea significantly decreased at three and six months in the insufficient group (P = 0.003).
Conclusion: Vitamin D deficiency is prevalent among kidney transplant recipients and affects graft function over time. Managing vitamin D levels could improve long-term graft outcomes, emphasizing the need for regular monitoring and supplementation.
Keywords
Kidney transplantation; Vitamin D deficiency; Graft function; eGFR, Immunosuppressants; Chronic kidney disease
Statistics
Article View: 207
PDF Download: 161