Addressing Childhood Obesity: An Interdisciplinary Approach in Biochemical Aspects, Public Health, Community Health, Epidemiology, and Pediatrics | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 13, December 2024, Page 1991-2003 PDF (454.71 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/ejchem.2025.345665.11010 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Naseabah Ali Mohammed Abu Haddash  ; Waheid Hadi Mohammed Abu Hadash; Waseem Hadi Mohammed Abu Hadash; Emad Hussain Mohammad Alagsam; Ghala Mohammed Bin Ibrahim Shajiri; Ali Mohammed Ali Kulaybi; Yahya Mohamed Gtabri Daghreri; Mohammed Rashed Mohammed; Mohammed Abduh Alshafyie; Ahmed Ibrahim Ibrahim Alkhawaji; Hanan Abdulrahman Abdulah Ali; Nawal Hassan Ali Moharid; Aisha Hassan Ali Moharid; Areej Ali Ali Awaji; Hanan Mohammed Abdullah Sarafi; Thuraya Saeed Mohammed Al Zahrani; Ahmed Ibrahim Mohammed Khuli; Nojood Mohammed Ahmed Hakami
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| Ministry of Health, Saudi Arabia | ||||
| Abstract | ||||
| Background: Childhood obesity is a significant global health concern associated with a spectrum of comorbidities, including type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). The complex interplay of genetic, physiological, environmental, and social factors has heightened its prevalence, warranting multidisciplinary intervention strategies. Aim: This study explores the latest developments in the pathophysiology, comorbidities, biochemical aspects, and management strategies for childhood obesity, emphasizing type 2 diabetes and CVD risk. Methods: A thorough literature review was conducted using PubMed to analyze original and review articles in English addressing pediatric obesity, T2DM, and CVD risk factors. Studies on epidemiology, pathophysiology, and interventions were included. Results: Childhood obesity prevalence is rising, exacerbated by socioeconomic, genetic, and environmental factors. Key findings highlight the significant role of adverse childhood experiences and metabolic dysregulation in obesity’s pathogenesis. Obesity-induced insulin resistance and β-cell dysfunction underpin the early onset of T2DM, with youth exhibiting more severe disease progression than adults. Treatment strategies include lifestyle modifications, pharmacotherapy, and bariatric surgery, yet their efficacy in pediatrics remains suboptimal. Comorbidities, including NAFLD and psychosocial impacts, further complicate management. Conclusion: Childhood obesity requires an interdisciplinary approach that integrates public health, pediatrics, epidemiology, and community health. Strategies should prioritize early intervention, preventive measures, and tailored therapeutic approaches to mitigate long-term health impacts. | ||||
| Keywords | ||||
| childhood obesity; type 2 diabetes mellitusand cardiovascular disease; pediatric healthand metabolic dysregulation; public health interventions | ||||
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