Evaluation of chitinase -3-like protein 1 Level in Patients with lichen planus
Abd-Elatif, M., Ali, E., Rashed, L., Naguib, R. (2025). Evaluation of chitinase -3-like protein 1 Level in Patients with lichen planus. EKB Journal Management System, 6(1), 22-26. doi: 10.21608/ejmr.2022.133135.1220
Mona El Sayed Ahmed Abd-Elatif; Esraa Mohamed Emam Ali; Laila Ahmed Rashed; Reham William Naguib. "Evaluation of chitinase -3-like protein 1 Level in Patients with lichen planus". EKB Journal Management System, 6, 1, 2025, 22-26. doi: 10.21608/ejmr.2022.133135.1220
Abd-Elatif, M., Ali, E., Rashed, L., Naguib, R. (2025). 'Evaluation of chitinase -3-like protein 1 Level in Patients with lichen planus', EKB Journal Management System, 6(1), pp. 22-26. doi: 10.21608/ejmr.2022.133135.1220
Abd-Elatif, M., Ali, E., Rashed, L., Naguib, R. Evaluation of chitinase -3-like protein 1 Level in Patients with lichen planus. EKB Journal Management System, 2025; 6(1): 22-26. doi: 10.21608/ejmr.2022.133135.1220

Evaluation of chitinase -3-like protein 1 Level in Patients with lichen planus

Egyptian Journal of Medical Research
Volume 6, Issue 1, January 2025, Pages 22-26    PDF (824.41 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2022.133135.1220
Authors
Mona El Sayed Ahmed Abd-Elatif1; Esraa Mohamed Emam Ali* 1; Laila Ahmed Rashed2; Reham William Naguib1
1Dermatology department, Faculty of Medicine, Beni-Suef University
2Biochemistry department, Faculty of Medicine, Cairo University
Abstract
Lichen planus (LP) is an idiopathic, chronic, inflammatory, autoimmune dermatological disorder characterized by keratinocytes apoptosis. The pathogenesis of LP appears multifactorial. chitinase-3-like protein1(CHI3L1) has been found to play a role in inflammation, proliferation and angiogenesis. The aim of the current study was to evaluate tissue CHI3L1 levels in skin biopsies of LP patients to investigate its role in LP pathogenesis. In 30 LP patients and 30 healthy controls, CHI3L1 level was estimated using Polymerase Chain Reaction (PCR) technique. The expression of CHI3L1 was significantly higher in tissue biopsies from LP lesions in comparison to normal control biopsies. Thus, CHI3L1 might participate in the pathogenesis of LP.     
Keywords
Lichen planus; Chitinase-3-like protein 1; skin biopsies
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